95337-70-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(2,5-DIMETHYL-1H-PYRROL-1-YL)BENZALDEHYDE is used as a key intermediate for the synthesis of atropine, a medication that is employed to counteract the effects of certain nerve agents and pesticide poisonings. It is also utilized to manage excessive salivation and respiratory secretions during surgical procedures.
Used in the Synthesis of Anticholinergic Drugs:
In the pharmaceutical industry, 4-(2,5-DIMETHYL-1H-PYRROL-1-YL)BENZALDEHYDE is used as a precursor in the production of other drugs that exhibit anticholinergic effects, which are beneficial in treating a variety of conditions by blocking the action of acetylcholine, a neurotransmitter.
Used in the Production of Cocaine:
4-(2,5-DIMETHYL-1H-PYRROL-1-YL)BENZALDEHYDE is also utilized as a precursor in the chemical synthesis of cocaine, highlighting its importance in the creation of substances with both medicinal and illicit uses.
Used in the Chemical Industry:
Beyond its pharmaceutical applications, 4-(2,5-DIMETHYL-1H-PYRROL-1-YL)BENZALDEHYDE is used as a building block in the chemical industry for the synthesis of a wide range of biologically active molecules, contributing to the development of new compounds with potential therapeutic and commercial value.

InChI:InChI=1/C13H13NO/c1-10-3-4-11(2)14(10)13-7-5-12(9-15)6-8-13/h3-9H,1-2H3

Upstream product

• 5044-24-6 1-(4-Bromo-phenyl)-2,5-dimethyl-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 106-40-1 4-bromo-aniline 
• 555-16-8 4-nitrobenzaldehdye 
• 110-13-4 2,5-hexanedione 

Downstream Products

• 95337-72-7 1,3-dithian-2-yl-<4-(2,5-dimethylpyrrol-1-yl)phenyl>methanol 
• 83756-25-6 2-<4-(2,5-dimethylpyrrol-1-yl)benzilidene>-1,3-dithian 
• 83756-26-7 2-<4-(2,5-dimethylpyrrol-1-yl)phenyl>propanoic acid 
• 5438-70-0 ethyl (4-amino-3,5-dibromophenyl)acetate 
• 59430-62-5 2-(4-aminophenyl)propionic acid 
• 1197-55-3 4-aminophenylacetic acid 
• 32868-25-0 2-(4-amminofenil)propionico d'etile 
• 26165-63-9 2-<4-(2,5-dimethylpyrrol-1-yl)phenyl>ethanoic acid 

Relevant academic research and scientific papers

One-pot synthesis of: N -substituted pyrroles from nitro compounds and 2,5-hexadione over a heterogeneous cobalt catalyst

In this study, the one-pot heterocyclization of nitro compounds with 2,5-hexadione was studied for the synthesis of N-substituted pyrroles via a Paal-Knorr condensation process. The heterogeneous cobalt-nitrogen catalyst (Co-Nx/C-800-AT) was found to be active for this reaction with formic acid. Formic acid served as a hydrogen donor for the transfer hydrogenation, and also acted as an acid catalyst. More importantly, this method was tolerant of other functional groups, and hence various N-substituted pyrroles were produced with good to excellent yields. The Co-Nx/C-800-AT catalyst was highly stable, and could be reused several times without loss of its catalytic activity.

Protection of Primary Amines as N-Substituted 2,5-Dimethylpyrroles

Protection of primary amine group is achieved by incorporating it into an N-substituted 2,5-dimethylpyrrole system.The method affords protection against strong bases and nucleophiles, heating with concentrated alkali, standard mineral acid work-up conditions, and various other reagents.Phenyl-, pyridil-, thiazolyl-, and alkyl-amines have been studied.All give trisubstituted pyrroles in high yield (>80percent) by reaction with hexane-2,5-dione.The pyrroles from the first three types are stable to storage; even the N-alkyl compounds can be used without difficulty.Regeneration of the amine group, by treatment with hydrxylamine hydrochloride, is efficient (80percent yield) with the phenyl, pyridyl, and alkyl compounds but less satisfactory (60 - 65percent generally but down to 25percent in two cases) with the thiazolyl derivatives.