953390-07-3

Basic information

• Product Name: 4-amino-5-cyano-N-(4-methylthiazol-2-yl)-1-phenyl-1H-pyrazole-3-carboximide
• CAS NO: 953390-07-3
• Molecular Weight: 324.366
• Mol File: 953390-07-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-5-cyano-N-(4-methylthiazol-2-yl)-1-phenyl-1H-pyrazole-3-carboximide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-5-cyano-N-(4-methylthiazol-2-yl)-1-phenyl-1H-pyrazole-3-carboximide(953390-07-3)
• EPA Substance Registry System: 4-amino-5-cyano-N-(4-methylthiazol-2-yl)-1-phenyl-1H-pyrazole-3-carboximide(953390-07-3)

Safety Data

• Hazardous Substances Data: 953390-07-3(Hazardous Substances Data)

Upstream product

• 107-14-2 chloroacetonitrile 

Relevant articles and documents

Utility of cyanoacetamides as precursors to pyrazolo-[3,4-d]pyrimidin-4-ones, 2-aryl-6-substituted 1,2,3-triazolo-[4,5-d]pyrimidines and pyrazolo[1,5-a]pyrimidine-3-carboxamides

Cyanoacetamides (7a-c) were prepared via reacting cyanoacetic acid (5) with amines in the presence of acetic anhydride. Compounds (7a-c) coupled with benzenediazonium chloride to yield the phenylhydrazones (8a-c). These reacted with chloroacetonitrile to yield aminopyrazolecarboxamides (11a-c). Reaction of (8a,b) with hydroxylamine hydrochloride in DMF in presence of anhydrous sodium acetate afforded the amino-1,2,3-triazolecarboxamides (36a,b). Also compounds (7a-c) reacted with dimethylformamide dimethylacetal (DMFDMA) to yield the enamines (9a-c) which react with hydrazine hydrate to afford the aminopyrazoles (16a-c). Compounds (16) and (36) reacted with DMFDMA to yield the title heterocyclic derivatives.