95353-17-6Relevant academic research and scientific papers
Microwave-assisted synthesis of 10-substituted isoalloxazines in the presence of solid acids
Chauhan,Singh, Ram,Geetanjali
, p. 1179 - 1184 (2007/10/03)
The microwave-enhanced synthesis of 10-substituted isoalloxazines is achieved rapidly (～4 min) and in good yield (>80-95%) via the cyclocondensation of 2-substituted aminoanilines with alloxan or N-methylalloxan monohydrate in the presence of acidic alumi
A new and improved N-3 alkylation of 10-substituted isoalloxazines using 1,8-diazabicyclo[5.4.0]undec-7-ene in benzene
Geetanjali,Singh, Ram,Chauhan
, p. 613 - 620 (2007/10/03)
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) has been identified as a remarkable base for the alkylation at N-3 position of 10-substituted isoalloxazines with alkyl halides in dry benzene.
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl)flavins
Cowden,Halladay,Cunningham,Hunt,Clark
, p. 1818 - 1822 (2007/10/02)
A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.
Flavin Activation by Intramolecular Acid Catalysis at N(1) Position
Shinkai, Seiji,Kawanabe, Sayuri,Kawase, Akito,Yamaguchi, Toshiro,Manabe, Osamu,et al.
, p. 2095 - 2102 (2007/10/02)
In order to assess the effect of intramolecular acid catalysis on the specific flavin reactivities, 3-methyl-10-(2-hydroxylphenyl)isoalloxazine (1(2OH)) and 3-methyl-10-(2-hydroxy-1-naphthyl)isoalloxazine (2(2OH)) were synthesized and the redox properties
