95360-33-1

Basic information

• Product Name: 4-(Chloromethyl)-phenylacetic acid methyl ester
• Synonyms: 4-(Chloromethyl)-phenylacetic acid methyl ester;2-(ChloroMethyl)-benzeneacetic acid Methyl ester;Methyl 2-[2-(Chloromethyl)Phenyl]Acetate;Methyl 2-[2-(Chloromethyl)Phenyl]Acetate(WX630300)
• CAS NO: 95360-33-1
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.65
• Mol File: 95360-33-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 272.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(Chloromethyl)-phenylacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Chloromethyl)-phenylacetic acid methyl ester(95360-33-1)
• EPA Substance Registry System: 4-(Chloromethyl)-phenylacetic acid methyl ester(95360-33-1)

Safety Data

• Hazardous Substances Data: 95360-33-1(Hazardous Substances Data)

Usage

Uses

2-(chloromethyl)-methyl ester benzeneacetic acid is a building block compound, and has been used as a component of Flavonoid as an aromatase inhibitor.

Upstream product

• 4385-35-7 isochroman-3-one 
• 67-56-1 methanol 
• 6772-67-4 2-chloromethylphenylacetyl chloride 
• 95335-46-9 2-chloromethylphenylacetic acid 

Downstream Products

• 187327-30-6 2-[6-(trifluoromethyl)-2-pyridyloxymethyl]phenylacetic acid methyl ester 
• 278611-07-7 methyl 2-(2-chloromethylphenyl)-3-hydroxyacrylate 
• 117428-95-2 methyl 2-(2'-chloromethylphenyl)-3-methoxyacrylate 
• 117428-22-5 picoxystrobin 
• 187327-31-7 (E)-methyl 2-[2-(6-trifluoromethylpyrid-2-yloxymethyl)phenyl]-3-hydroxyacrylate 
• 1370713-77-1 C₁₆H₁₈N₂O₄ 
• 1370713-75-9 C₁₆H₂₀N₂O₂ 
• 1248592-21-3 methyl [2-(1H-imidazol-1-ylmethyl)phenyl]acetate 
• 1370713-81-7 C₁₃H₁₃N₃ 
• 1370713-80-6 C₁₃H₁₅N₃O 
• 1370713-78-2 C₁₅H₁₉N₃O 

Relevant articles and documents

Method for preparing 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate

The invention provides a method for preparing methyl 2-(6-trifluoromethylpyridine-2-yloxymethyl) phenylacetate, and belongs to the technical field of preparation of pesticide intermediates. The preparation method comprises the following steps: by taking 3

Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects in Vivo

Signal peptide peptidase-like 2a (SPPL2a) is an aspartic intramembrane protease which has recently been shown to play an important role in the development and function of antigen presenting cells such as B lymphocytes and dendritic cells. In this paper, we describe the discovery of the first selective and orally active SPPL2a inhibitor (S)-2-cyclopropyl-N1-((S)-5,11-dioxo-10,11-dihydro-1H,3H,5H-spiro[benzo[d]pyrazolo[1,2-a][1,2]diazepine-2,1′-cyclopropan]-10-yl)-N4-(5-fluoro-2-methylpyridin-3-yl)succinamide 40 (SPL-707). This compound shows adequate selectivity against the closely related enzymes γ-secretase and SPP and a good pharmacokinetic profile in mouse and rat. Compound 40 significantly inhibited processing of the SPPL2a substrate CD74/p8 fragment in rodents at doses ≤10 mg/kg b.i.d. po. Oral dosing of 40 for 11 days at ≥10 mg/kg b.i.d. recapitulated the phenotype seen in Sppl2a knockout (ko) and ENU mutant mice (reduced number of specific B cells and myeloid dendritic cells). Thus, we believe that SPPL2a represents an interesting and druggable pharmacological target, potentially providing a novel approach for the treatment of autoimmune diseases by targeting B cells and dendritic cells.

NOVEL CRYSTALLINE FORM OF PICOXYSTROBIN, METHOD OF PREPARING AND USE OF THE SAME

A novel crystalline form of the compound of formula (I) (picoxystrobin) is provided. The novel crystalline form of picoxystrobin may be prepared by crystallization from solution in a suitable solvent. Fungicidal compositions comprising the novel crystalline form, a method for controlling fungal infestations at a locus and a use of the novel crystalline form are also provided.