117428-95-2

Upstream product

• 67-56-1 methanol 
• 95360-33-1 methyl 2-(chloromethyl)phenylacetate 
• 107-31-3 Methyl formate 
• 149-73-5 trimethyl orthoformate 
• 4385-35-7 isochroman-3-one 
• 278611-08-8 methyl 2-(2-chloromethyl phenyl)-3,3-dimethoxypropionate 
• 278611-07-7 methyl 2-(2-chloromethylphenyl)-3-hydroxyacrylate 

Downstream Products

• 178813-81-5 fluacrypyrim 
• 1392238-28-6 C₁₉H₂₀F₃N₃O₄ 
• 139752-37-7 2-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxymethyl)phenyl]-3-methoxyacrylic acid methyl ester 

Relevant academic research and scientific papers

Preparation method of picoxystrobin intermediate 2-(2-chloromethyl phenyl)-3-methyl methoxyacrylate

The invention relates to the field of organic synthesis, in particular to a preparation method of picoxystrobin intermediate 2-(2-chloromethyl phenyl)-3-methyl methoxyacrylate. The preparation methodincludes: subjecting 3-isochromanone serving as the raw

PREPARATION METHOD FOR ACRYLATE COMPOUND

The present invention relates to a method for preparing an acrylate compound. The acrylate compound has a structure as shown in formula (I). The method includes: subjecting a compound with a structure of formula (II) or a mixture of compounds with structures of formula (I) and formula (II), and a catalyst to a contact reaction in the absence of an anhydride, and removing the resulting methanol by pressure reduced distillation during the contact reaction process. In the formulas (I) and (II), R is selected from one of: an alkoxy with a carbon number of 1-5, a substituent-containing phenoxyl with a carbon number of 6-20, a substituent-containing heteroaryloxy with a carbon number of 4-20, a substituent-containing heteroaryloxymethyl with a carbon number of 4-20, a substituent-containing phenoxymethyl with a carbon number of 5-20, and a substituent-containing alkyl with a carbon number of 2-20. According to the method for preparing an acrylate compound provided in the invention, the conversion rate and selectivity of the reaction can be substantially improved.

Process for producing acrylic acid derivative

Processes for producing a compound represented by the formula (1), which includes an acrylic acid derivative and is useful as an agricultural chemical or medicine. One of the processes comprises the step of formulating a compound (3) and converting the OH of the resultant compound (2) into OR″. The first step comprises reacting a formic or orthoformic ester in the presence of a Lewis acid and a base. The second step comprises reacting the compound with R″OH or with R″OH and CH(OR″)3 under acidic conditions or using a phase-transfer catalyst in a two-phase system and regulating the base and the concentration thereof to stereoselectively synthesize the target compound. In another, process, the compound is efficiently produced without isolating the compound. The compound can also be produced without the compound (2).