953787-47-8

Usage

Uses

Used in Organic Synthesis:
2-Chloromethyl-3,4-dimethoxypyridine-N-oxide is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for a wide range of chemical reactions, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloromethyl-3,4-dimethoxypyridine-N-oxide is used as a key intermediate in the synthesis of drugs with potential therapeutic applications. Its versatility in organic synthesis enables the development of new drug candidates with improved efficacy and safety profiles.
Used in Agrochemical Industry:
2-Chloromethyl-3,4-dimethoxypyridine-N-oxide is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and herbicides. Its ability to participate in various chemical reactions allows for the creation of novel compounds with enhanced pest control properties.

InChI:InChI=1/C8H10ClNO3/c1-12-7-3-4-10(11)6(5-9)8(7)13-2/h3-4H,5H2,1-2H3

Upstream product

• 72830-09-2 2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride 

Downstream Products

• 953787-51-4 5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole 
• 953787-55-8 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole 

Relevant academic research and scientific papers

Method for preparing pantoprazole nitrogen oxide

The invention provides a preparation method of pantoprazole nitrogen oxide, which is implemented according to the following steps: reacting 2-chloromethyl-3, 4-dimethoxypyridine hydrochloride servingas a raw material with m-chloroperoxybenzoic acid, and carrying out oxidization to prepare pyridine nitrogen oxide; and enabling the pyridine nitrogen oxide to react with 5-difluoromethoxy-2-mercapto-1H-benzimidazole to generate 5-difluoromethoxy-2-[(3, 4-dimethoxy-2-pyridyl) methyl] thio-1H-benzimidazole nitrogen oxide. The genetically toxic impurity pantoprazole nitrogen oxide of the pantoprazole sodium sesquihydrate is prepared by an economical and green method, the operation is simple and convenient, the condition is mild, and the product purity is high.

Efficient synthesis of N-Oxide derivatives: Substituted 2-(2-(pyridyl-N-oxide)methylsulphinyl)benzimidazoles

Different substituted 2-chloromethylpyridyl derivatives (6a-d) were oxidized with mCPBA to give the respective 2-chloromethylpyridine-N-oxide derivatives (7a-d) at low temperature, which on condensation with 2-mercapto-1H-benzimidazole (8a-c) in the presence of aprotic solvents give the 2-[[(pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzimidazole (9a-d) in good yield. Finally, 9a-d oxidized with mCPBA in chlorinated solvent gives a mixture of 2-[[(pyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole (3a-d, 10%) and 2-[[(pyridin-2-yl-1-oxide) methyl]sulfinyl]-1H-benzimidazole (4a-d, 90%) derivatives. Copyright Taylor & Francis Group, LLC.