145015-15-2

Basic information

• Product Name: 2-CHLORO-5-HYDROXYMETHYLTHIAZOLE
• Synonyms: (2-CHLORO-1,3-THIAZOL-5-YL)METHANOL;2-CHLORO-5-HYDROXYMETHYLTHIAZOLE;2-Chloro-5-(hydroxymethyl)-1,3-thiazole;(2-Chlorothiazol-5-yl)methanol;5-ThiazoleMethanol, 2-chloro-
• CAS NO: 145015-15-2
• Molecular Formula: C₄H₄ClNOS
• Molecular Weight: 149.6
• Mol File: 145015-15-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 96°C 0,2mm
• Flash Point: 136.9°C
• Appearance: /
• Density: 1.528
• Vapor Pressure: 0.000427mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: 2-8°C
• PKA: 13.25±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-HYDROXYMETHYLTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-HYDROXYMETHYLTHIAZOLE(145015-15-2)
• EPA Substance Registry System: 2-CHLORO-5-HYDROXYMETHYLTHIAZOLE(145015-15-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 145015-15-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-hydroxymethylthiazole is a chemical compound with the molecular formula C4H5ClN2OS. It is a thiazole derivative that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-CHLORO-5-HYDROXYMETHYLTHIAZOLE possesses a chloro group and a hydroxymethyl group attached to a thiazole ring, making it a versatile intermediate for the production of various biologically active molecules. It is also known for its use in the preparation of thiamine analogs, which are important for the treatment and prevention of thiamine deficiency-related disorders. Additionally, it has been studied for its antimicrobial and antifungal properties, making it a potential candidate for the development of new drugs.

InChI:InChI=1/C4H4ClNOS/c5-4-6-1-3(2-7)8-4/h1,7H,2H2

Upstream product

• 1634-04-4 tert-butyl methyl ether 
• 7440-44-0 pyrographite 
• 105827-91-6 α-Cl-β-thiazolyl chloride 
• 95453-58-0 2-chloro-1,3-thiazole-5-carbaldehyde 

Downstream Products

• 105827-91-6 α-Cl-β-thiazolyl chloride 
• 101012-12-8 2-chloro-1,3-thiazole-5-carboxylic acid 
• 38585-74-9 thiazol-5-yl-methanol 
• 848567-58-8 (2-chloro-thiazol-5-yl)methyl-3-phenyl-2-propenoate 

Relevant articles and documents

TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS

The present invention provides a compound of the formula: Formula I or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or ex

Intermediate thiazoles and process for the preparation of 2-chloro-5-chloromethyl-thiazole

The present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethylthiazole which is a known compound useful for the preparation of insecticides.

Process for the preparation of 5-hydroxymethylthiazoles

The present invention discloses a process for the preparation of a hydroxymethylthiazole compound having formula 3: The process of the invention comprises reacting a halomethyl thiazole having the formula: STR1 with water, at an elevated temperature. Optionally, the reaction can be carried out in the presence of a base, such as sodium carbonate, which can react with any acid formed. In the process of the invention, X is a halogen atom; and R6 is selected from the group consisting of hydrogen, and halogen atoms. The invention also contemplates the preparation of acid addition salts of the hydroxymethylthiazole, compound 3.