95479-48-4

Basic information

• Product Name: 2(5H)-Furanone, 3,4-bis(4-chlorophenyl)-
• CAS NO: 95479-48-4
• Molecular Formula: C16H10Cl2O2
• Molecular Weight: 305.16
• Mol File: 95479-48-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 3,4-bis(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 3,4-bis(4-chlorophenyl)-(95479-48-4)
• EPA Substance Registry System: 2(5H)-Furanone, 3,4-bis(4-chlorophenyl)-(95479-48-4)

Safety Data

• Hazardous Substances Data: 95479-48-4(Hazardous Substances Data)

Upstream product

• 95479-46-2 (E)-2,3-Bis-(4-chloro-phenyl)-but-2-enedial 
• 1679-18-1 4-Chlorophenylboronic acid 
• 62674-12-8 3,4-dichloro-5H-furan-2-one 
• 17151-48-3 tributyl(4-chlorophenyl)stannane 
• 1878-66-6 4-chlorophenylacetic Acid 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 95479-43-9 C₁₆H₁₀Br₂Cl₂ 
• 95479-41-7 C₁₆H₁₂Cl₂ 
• 24314-35-0 1,4-bis(4-chlorophenyl)butane-1,4-dione 

Downstream Products

• 576169-61-4 3,4-bis(4-chlorophenyl)furan 

Relevant articles and documents

2-FURANCARBOXYLIC ACID HYDRAZIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula(I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof, methods for producing them and pharmaceutical compositions containing them: wherein A is a group represented by Formula (a) or the like: (wherein either R4 or R5 represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R1 or R2 represents a group: -D-(X)m-R6 or the like, and the other represents a group: -E-(Y)n-R7, hydrogen atom, aryl or the like; R3 is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent 0 or the like; R6 and R7 independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted. Such compounds exhibit a potent antagonistic activity on glucagon receptor and are of use as preventive and/or therapeutic agents for symptoms and diseases in which glucagon is involved.

Total synthesis of rubrolide M and some of its unnatural congeners

Two protocols have been developed for the Pd-catalyzed regioselective synthesis of 4-aryl-3-chloro-2(5H)-furanones starting from 3,4-dichloro-2(5H)-furanone. These monochloro derivatives have then been used as precursors to (Z)-4-aryl-5-[1-(aryl)methylidene]-3-chloro-2(5H)-furanones including naturally-occurring rubrolide M.