95479-52-0Relevant academic research and scientific papers
SYNTHESIS OF 4H-BENZO[D]PYRROLO[1,2-A]THIAZOLES AND INDOLIZINO[6,7-b]INDOLE DERIVATIVES AND THEIR USE AS ANTITUMOR THERAPEUTIC AGENTS
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Paragraph 0097, (2013/07/19)
The present invention provides a series of 2,3-bis(hydroxymethyl)-4H-benzo[d]pyrrolo-[1,2-a]thiazoles and 1,2-bis(hydroxymethyl)indolizino[6,7-b]indole derivatives and their bis(alkylcarbamates) derivatives. These derivatives were designed as bi-functiona
Synthesis and antitumor evaluation of novel Benzo[d]pyrrolo[2,1-b]thiazole derivatives
Chaniyara, Ravi,Tala, Satishkumar,Chen, Chi-Wei,Lee, Pei-Chih,Kakadiya, Rajesh,Dong, Huajin,Marvania, Bhavin,Chen, Ching-Huang,Chou, Ting-Chao,Lee, Te-Chang,Shah, Anamik,Su, Tsann-Long
experimental part, p. 28 - 40 (2012/07/30)
A series of novel 2,3-bis(hydroxymethyl)benzo[d]pyrrolo[2,1-b]thiazoles and their bis(alkylcarbamate) derivatives were synthesized starting from benzothiazole via reaction with dimethyl acetylenedicarboxylate (DMAD)/tetra-fluoro boric acid, catalytic hydr
Reissert Compound Formation with Fused Five-Membered Ring Heterocycles
Uff, Barrie C.,Ho, Yee-Ping,Brown, David S.,Fisher, Ian,Popp, Frank D.,Kant, Joydeep
, p. 2652 - 2681 (2007/10/02)
Reissert compounds have been prepared in high yield from benzothiazole by use of trimethylsilyl cyanide as source of cyanide in a single phase system.Analogues have been made from benzoxazole, indazole and 1-methylindazole but the method was unsuccessful with 1,2-benzisoxazole and pyrazole.Conjugate base alkylation followed by removal of the Reissert grouping provides a route to 2-alkylbenzothiazoles and -benzoxazoles, and 3-alkylated indazoles.Efficient access to pyridobenzothiazole and benzothiazoloisoquinoline derivatives results from appropriate intramolecular cyclisations.A crystal structure determination of 3-benzoyl-2,3-dihydro-2-benzothiazolecarbonitrile is reported.
Reissert Compound Formation with Five-membered Ring Heterocycles using Trimethylsilyl Cyanide
Uff, Barrie C.,Chen, S. L. Anne A.,Ho, Yee-Ping,Popp, Frank D.,Kant, Joydeep
, p. 1245 - 1246 (2007/10/02)
Treatment of benzothiazole with trimethylsilyl cyanide and an acid chloride in CH2Cl2 gives the N-acyl-2-cyano-2,3-dihydrobenzothiazole in good yield; benzoxazole similarly is converted into a five-membered ring Reissert compound, providing the first exam
