955-37-3Relevant academic research and scientific papers
Isothiourea-catalyzed enantioselective α-alkylation of esters via 1,6-conjugate addition to para-quinone methides
Arokianathar, Jude N.,Greenhalgh, Mark D.,Hartley, Will C.,McLaughlin, Calum,Ng, Sean,Slawin, Alexandra M. Z.,Smith, Andrew D.,Stead, Darren
supporting information, (2021/11/01)
The isothiourea-catalyzed enantioselective 1,6-conjugate addition of para-nitrophenyl esters to 2,6-disubstituted para-quinone methides is reported. para-Nitrophenoxide, generated in situ from initial N-acylation of the isothiourea by the para-nitrophenyl ester, is proposed to facilitate catalyst turnover in this transformation. A range of para-nitrophenyl ester products can be isolated, or derivatized in situ by addition of benzylamine to give amides at up to 99% yield. Although low diastereocontrol is observed, the diastereoisomeric ester products are separable and formed with high enantiocontrol (up to 94:6 er).
