95516-21-5

Basic information

• Product Name: (Z)-3-(3-Chloro-phenylcarbamoyl)-acrylic acid methyl ester
• CAS NO: 95516-21-5
• Molecular Weight: 239.658
• Mol File: 95516-21-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-3-(3-Chloro-phenylcarbamoyl)-acrylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(3-Chloro-phenylcarbamoyl)-acrylic acid methyl ester(95516-21-5)
• EPA Substance Registry System: (Z)-3-(3-Chloro-phenylcarbamoyl)-acrylic acid methyl ester(95516-21-5)

Safety Data

• Hazardous Substances Data: 95516-21-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 18196-80-0 (Z)-4-((3-chlorophenyl)amino)-4-oxobut-2-enoic acid 

Downstream Products

• 106691-40-1 N-(3-chlorophenyl)-2-(3-oxo-1,4-benzothiazin-2-yl) acetamide 
• 915711-60-3 (E)-3-(3-Chloro-phenylcarbamoyl)-acrylic acid methyl ester 

Relevant articles and documents

Synthesis and antifungal activity of N-(alkyl/aryl)-2-(3-oxo-1,4- benzothiazin-2-yl)acetamide

A series of N-(alkyl/aryl)-2-(3-oxo-1,4-benzothiazin-2-yl)acetamide have been synthesized by condensation of substituted amines with maleic anhydride (MA) followed by cyclization with o-aminothiophenol (o-ATP). All the compounds have been screened for their antifungal activity against Tricophyton rubrum, Epidermophyton floccosum and Malassazia furfur. In the primary screening, some of the compounds exhibited appreciable activity. The structures of the synthesized compounds 7a-z have been established on the basis of elemental analysis and spectral data.

ESTERIFICATION AT ROOM TEMPERATURE: A MIXING AFFAIR ONLY

Carboxylic acids in absolute alcohols, on treatment with thionyl chloride at room temperature give good yields of corresponding esters.