955879-81-9Relevant academic research and scientific papers
Compounds and Methods of Treatment
-
Page/Page column 23, (2008/12/08)
A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.
The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors
Graham Robinett,Freemerman, Alex J.,Skinner, Michael A.,Shewchuk, Lisa,Lackey, Karen
, p. 5886 - 5893 (2008/03/14)
Substituted 4-(3-hydroxyanilino)-quinoline compounds, initially identified as small-molecule inhibitors of src family kinases, have been evaluated as potential inhibitors of RET kinase. Three compounds, 38, 31, and 40, had Ki's of 3, 25, and 50
