95588-06-0Relevant articles and documents
Catalytic Enantioselective Synthesis of α-(Benzylamino)cyclobutanones
Melis, Nicola,Ghisu, Lorenza,Guillot, Régis,Caboni, Pierluigi,Secci, Francesco,Aitken, David J.,Frongia, Angelo
, p. 4258 - 4266 (2015)
An organocatalytic enantioselective synthesis of α-(benzylamino)cyclobutanones has been achieved by employing a tandem condensation/intramolecular rearrangement/proton transfer reaction and starting from racemic α-hydroxycyclobutanone and a selection of benzylamines. This reaction sequence afforded the products in good to high yields with moderate to high enantioselectivities. An organocatalytic enantioselective synthesis of α-(benzylamino)cyclobutanones has been achieved by employing a tandem condensation/intramolecular rearrangement/proton transfer reaction. The reaction sequence began from readily available racemic α-hydroxycyclobutanone and a variety of benzylamines to afford the products in good to high yields and with moderate to high stereoselectivities.
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 1896-1898, (2020/05/14)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
Synthesis of quaternary α-benzyl- and α-allyl-α-methylamino cyclobutanones: Dedicated to Professor Achille Umani Ronchi for his 80th birthday
Ghisu, Lorenza,Melis, Nicola,Secci, Francesco,Caboni, Pierluigi,Frongia, Angelo
supporting information, p. 8201 - 8209 (2016/12/02)
A simple and practical protocol for the construction of synthetically important quaternary α-benzyl- and α-allyl-α-methylamino cyclobutanones in good to high yield, via a sequential one-pot methylation/sigmatropic rearrangement, has been accomplished for
