955955-05-2Relevant academic research and scientific papers
Regioselective one-step synthesis of pyrazoles from alkynes and N-tosylhydrazones: [3+2] dipolar cycloaddition/[1,5] sigmatropic rearrangement cascade
Pérez-Aguilar, M. Carmen,Valdés, Carlos
supporting information, p. 7219 - 7223 (2013/07/26)
Rearrangement under control: A wide variety of 3,4,5- and 1,3,5-trisubstituted pyrazoles can be prepared from tosylhydrazones of ketones and terminal alkynes through the title reaction sequence (see scheme; Ts=4-toluenesulfonyl). The rearrangement, and th
Structure-Activity Relationships Associated with 3,4,5-Triphenyl-1H-pyrazole-1-nonanoic Acid, a Nonprostanoid Prostacyclin Mimetic
Meanwell, Nicholas A.,Rosenfeld, Michael J.,Wright, J. J. Kim,Brassard, Catherine L.,Buchanan, John O.,et al.
, p. 389 - 397 (2007/10/02)
A series of phenylated pyrazoloalkanoic acid derivatives were synthesized and evaluated as inhibitors of ADP-induced human platelet aggregation. 3,4,5-Triphenyl-1H-pyrazole-1-nonanoic acid (8d), with an IC50 of 0.4 μM, was the most potent inhibitor identi
