956095-91-3

Basic information

• Product Name: N-cyclohexylquinazolin-2-amine
• Synonyms: N-cyclohexylquinazolin-2-amine
• CAS NO: 956095-91-3
• Molecular Weight: 227.309
• Mol File: 956095-91-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-cyclohexylquinazolin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexylquinazolin-2-amine(956095-91-3)
• EPA Substance Registry System: N-cyclohexylquinazolin-2-amine(956095-91-3)

Safety Data

• Hazardous Substances Data: 956095-91-3(Hazardous Substances Data)

Upstream product

• 40138-16-7 2-formylbenzene boronic acid 
• 2498-47-7 N-cyclohexylguanidine hydrochloride 
• 931-53-3 Cyclohexyl isocyanide 
• 4403-69-4 2-amino-1-benzylamine 
• 6141-13-5 2-chloroquinazoline 
• 108-91-8 cyclohexylamine 
• 1687-51-0 quinazolin-2-ylamine 
• 108-93-0 cyclohexanol 

Relevant articles and documents

I2/TBHP-Mediated Oxidative Coupling of Amino-Based Bisnucleophiles and Isocyanides: Access to 2-Aminobenzoxazinones, 2-Aminobenzoxazines, and 2-Aminoquinazolines under Metal-Free Conditions

An I2/tert-butyl hydroperoxide (TBHP)-mediated oxidative coupling reaction of isocyanides with amino-based bisnucleophiles is described for the synthesis of 2-aminobenzoxazinones, 2-aminobenzoxazines, and 2-aminoquinozolines in moderate to exce

Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

We report herein a high-temperature and high-pressure continuous-flow protocol to carry out nucleophilic aromatic substitution (SNAr) of heterocycles with nitrogen nucleophiles. Utilizing the Phoenix Flow Reactor in parallel with Design-of-Experiment software enabled rapid optimization of the SNAr protocol. This protocol facilitated efficient synthesis of a broad range of 2-aminoquinazolines, and was extended to 2-aminoquinoxalines and 2-aminobenzimidazoles.