956100-62-2

Usage

Uses

Used in Medicinal Chemistry:
4-Amino-8-bromo-2-chloroquinazoline is used as a pharmaceutical precursor for the development of drugs, leveraging its biological activity to create new therapeutic agents.
Used in Organic Synthesis:
In the field of organic chemistry, 4-Amino-8-bromo-2-chloroquinazoline is used as a building block for synthesizing more complex organic compounds, contributing to the advancement of chemical libraries and the discovery of novel molecules with specific properties.
Used in Materials Science:
4-Amino-8-bromo-2-chloroquinazoline is utilized in materials science for its potential to contribute to the development of new materials with unique properties, such as those used in organic electronics.
Used in Organic Electronics:
In the industry of organic electronics, 4-Amino-8-bromo-2-chloroquinazoline is employed for its potential role in creating electronic components and devices that are more efficient, flexible, or have other advantageous characteristics.

Upstream product

• 20776-51-6 2-amino-3-bromo benzoic acid 
• 331646-99-2 8-bromoquinazoline-2,4-(1H,3H)-dione 
• 331646-99-2 8-bromoquinazoline-2,4-diol 
• 331647-05-3 8-bromo-2,4-dichloroquinazoline 

Downstream Products

• 956100-63-3 8-bromo-2-chloroquinazoline 

Relevant academic research and scientific papers

BETA-ADRENERGIC RECEPTOR ALLOSTERIC MODULATORS

Provided herein are modulators of beta-adrenergic receptors.

CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF

Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b' to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.

FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, Z1, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I).