956100-63-3

Basic information

• Product Name: 8-BROMO-2-CHLOROQUINAZOLINE
• Synonyms: 8-BROMO-2-CHLOROQUINAZOLINE;8-BroMo-2-chloroquinazoli...
• CAS NO: 956100-63-3
• Molecular Formula: C₈H₄BrClN₂
• Molecular Weight: 243.5
• Product Categories: CHIRAL CHEMICALS
• Mol File: 956100-63-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 232.7 °C at 760 mmHg
• Flash Point: 94.5 °C
• Appearance: /
• Density: 1.762
• Refractive Index: 1.691
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.09±0.30(Predicted)
• CAS DataBase Reference: 8-BROMO-2-CHLOROQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-2-CHLOROQUINAZOLINE(956100-63-3)
• EPA Substance Registry System: 8-BROMO-2-CHLOROQUINAZOLINE(956100-63-3)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 956100-63-3(Hazardous Substances Data)

Usage

General Description

8-Bromo-2-chloroquinazoline is a chemical compound with the molecular formula C8H5BrClN3. It is a heterocyclic compound containing both bromine and chlorine atoms, as well as a quinazoline ring structure. 8-BROMO-2-CHLOROQUINAZOLINE has potential applications in pharmaceutical and chemical research, due to its unique structure and reactivity. It can be used as a building block in the synthesis of biologically active compounds, or as a starting material for the development of new medications. Additionally, 8-Bromo-2-chloroquinazoline may also have uses in the development of agrochemicals, dyes, and other industrial products. Its properties make it an interesting and valuable chemical for further exploration and development.

InChI:InChI=1/C8H4BrClN2/c9-6-3-1-2-5-4-11-8(10)12-7(5)6/h1-4H

Upstream product

• 331646-99-2 8-bromoquinazoline-2,4-diol 
• 331646-99-2 8-bromoquinazoline-2,4-(1H,3H)-dione 
• 20776-51-6 2-amino-3-bromo benzoic acid 
• 331647-05-3 8-bromo-2,4-dichloroquinazoline 
• 956100-62-2 8-bromo-2-chloroquinazolin-4-amine 

Downstream Products

• 1660963-42-7 N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide 

Relevant articles and documents

CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF

Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b' to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.