956325-21-6Relevant academic research and scientific papers
Facile Synthesis of Onychines
Arita, Mao,Yokoyama, Soichi,Asahara, Haruyasu,Nishiwaki, Nagatoshi
, p. 2007 - 2013 (2019/04/26)
The FeCl 3 -mediated condensation of an α-phenylenamino ester and an enone proceeds efficiently to afford a 2-phenylnicotinate. The subsequent intramolecular Friedel-Crafts reaction yielded an onychine framework. Modifications at the 2-, 3-, and 8-positions of the onychine framework were easily achieved by altering the enamino esters and enones, which facilitated the discovery of potentially bioactive compounds.
The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents
Taghavi-Moghadam, Shahriyar,Kwong, Cecil D.,Secrist, John A.,Khan, Shabana I.,Clark, Alice M.
, p. 6119 - 6130 (2016/12/06)
Eupolauridine, an indenonaphthyridine alkaloid, has been previously reported by us to exhibit antifungal activity. This study describes the synthesis of new alkyl and benzyl naphthyridinium/pyridinium analogs of eupolauridine as potential antifungal agent
Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar dry forest
Pan, Ende,Cao, Shugeng,Brodie, Peggy J.,Callmander, Martin W.,Randrianaivo, Richard,Rakotonandrasana, Stephan,Rakotobe, Etienne,Rasamison, Vincent E.,TenDyke, Karen,Shen, Yongchun,Suh, Edward M.,Kingston, David G. I.
experimental part, p. 1169 - 1174 (2011/07/30)
Investigation of the Madagascan endemic plant Ambavia gerrardii for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the three new alkaloids 8-hydroxyeupolauridine (1), 9-methoxyeupolauridine 1-oxide (2), and 1
