956397-18-5

Usage

Uses

Used in Pharmaceutical Synthesis:
3-TERT-BUTYL-1-(2-CHLOROPHENYL)-1H-PYRAZOL-5-AMINE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 3-TERT-BUTYL-1-(2-CHLOROPHENYL)-1H-PYRAZOL-5-AMINE is used as a precursor in the creation of various agrochemicals, potentially enhancing crop protection and yield.
Used in Research and Development:
3-TERT-BUTYL-1-(2-CHLOROPHENYL)-1H-PYRAZOL-5-AMINE is utilized as a research compound for exploring its chemical properties and potential applications in different areas of science, including medicinal chemistry and drug discovery.
Further studies and research are necessary to fully explore the capabilities and applications of 3-TERT-BUTYL-1-(2-CHLOROPHENYL)-1H-PYRAZOL-5-AMINE across various scientific and industrial fields.

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 10449-07-7 (2-chlorophenyl)hydrazine 

Relevant academic research and scientific papers

Biophysical investigation and conformational analysis of p38α kinase inhibitor doramapimod and its analogues

Doramapimod (BIRB 796) is a potent inhibitor of p38α mitogen-activated protein kinase. It contains an aryl-pyrazole scaffold as a pharmacophore critical for binding. The aryl-pyrazole scaffold is not planar and adopts an out-of-plane conformation, which is described by the torsion angle θ. In this letter, we report the chemical synthesis and biophysical characterization of different analogues of doramapimod (3-12) exhibiting distinctly different aryl-pyrazole torsion angle θ values. The torsion angle θ values of the synthesized analogues (3-6) were determined by crystal structural analysis and the binding affinities to p38α kinase investigated by microscale thermophoresis. Our results unveil a clear correlation between kinase binding and the torsion angle θ of tested doramapimod analogues, highlighting the importance of inhibitor conformation for protein binding.

PHENYLACETAMIDES SUITABLE AS PROTEIN KINASE INHIBITORS

The invention relates to compounds of the formula (I) wherein the moieties R1 , R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof; as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.