956470-93-2Relevant academic research and scientific papers
Synthesis of β-Difluoroalkylated Acrylonitriles in the Presence of Copper Powder
He, Yu-Tao,Li, Lian-Hua,Wang, Qiang,Wu, Wangsuo,Liang, Yong-Min
, p. 5158 - 5161 (2016)
A highly regio- and stereoselective copper-mediated cyanodifluoroalkylation of alkynes with ethyl difluoroiodoacetate and trimethylsilyl cyanide (TMSCN) is described. The three-component coupling reaction provides straightforward access to a variety of us
Visible light photocatalytic cross-coupling and addition reactions of arylalkynes with perfluoroalkyl iodides
Cheng, Shun-Cheung,Chun, Yuen-Kiu,Ko, Chi-Chiu,Liu, Ruoyang,Tse, Man-Kit,Xiao, Yelan
, p. 8686 - 8693 (2020/11/17)
Visible light photocatalytic cross-coupling and addition reactions of arylalkynes with perfluoroalkyl iodides have been developed. Through slight modifications of the reaction conditions, reactions that are selective for the preparation of the C-C couplin
Blue Light Induced Difluoroalkylation of Alkynes and Alkenes
Li, Kangkui,Zhang, Xuexin,Chen, Jingchao,Gao, Yang,Yang, Chunhui,Zhang, Keyang,Zhou, Yongyun,Fan, Baomin
supporting information, p. 9914 - 9918 (2019/12/24)
The difluoroalkylation of alkynes and alkenes by direct photoexcitation of ethyl difluoroiodoacetate is described. Under catalyst- and oxidant-free conditions, iododifluoroalkylation and hydrodifluoroalkylation products were generated from alkynes, and difluoroalkylation products were prepared from alkenes. This methodology provides a streamlined access to difluoroalkylated organic compounds starting from simple alkynes or alkenes.
Method for preparing difluoroiodo-olefin
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Paragraph 0041-0044, (2019/12/25)
The invention belongs to the field of iodo-difluoro alkylation of alkynes and particularly relates to a method for preparing difluoroiodo-olefin. The method comprises the steps: (1) taking the alkynesas a starting raw material, adding accurate-weighed alk
Stereoselective cobalt-catalyzed halofluoroalkylation of alkynes
Wu, Guojiao,Jacobi Von Wangelin, Axel
, p. 1795 - 1802 (2018/02/23)
Stereoselective additions of highly functionalized reagents to available unsaturated hydrocarbons are an attractive synthetic tool due to their high atom economy, modularity, and rapid generation of complexity. We report efficient cobalt-catalyzed (E)-halofluoroalkylations of alkynes/alkenes that enable the construction of densely functionalized, stereodefined fluorinated hydrocarbons. The mild conditions (2 mol% cat., 20 °C, acetone/water, 3 h) tolerate various functional groups, i.e. halides, alcohols, aldehydes, nitriles, esters, and heteroarenes. This reaction is the first example of a highly stereoselective cobalt-catalyzed halo-fluoroalkylation. Unlike related cobalt-catalyzed reductive couplings and Heck-type reactions, it operates via a radical chain mechanism involving terminal halogen atom transfer which obviates the need for a stoichiometric sacrificial reductant.
Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides
Ma, Jing-Jing,Yi, Wen-Bin
supporting information, p. 4295 - 4299 (2017/07/10)
Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. A variety of fluoroalkyl halides including ethyl bromodifluoroacetate can be employed. Additionally, an unprecedented decarboxylative fluoroalkylation of α, β-unsaturated carboxylic acids has been achieved via a radical pathway.
Platinum(II) photo-catalysis for highly selective difluoroalkylation reactions
Zhong, Jian-Ji,Yang, Chen,Chang, Xiao-Yong,Zou, Chao,Lu, Wei,Che, Chi-Ming
supporting information, p. 8948 - 8951 (2017/08/15)
The platinum(ii) photo-catalyzed difluoroalkylation of cinnamic acids and alkynes for selective construction of E-,Z-difluoroalkyl alkenes and difluoroalkyl alkenyl iodides, respectively, were achieved under mild conditions. The high efficiency, good substrate scope and high selectivity altogether highlight the prospect of Pt(ii) photocatalysts in visible-light-driven organic transformation reactions.
Copper-Catalyzed Decarboxylative Atom Transfer Radical Addition of Iododifluoroacetate to Alkynyl Carboxylic Acids
Li, Gang,Cao, Yi-Xuan,Luo, Chen-Guang,Su, Yi-Ming,Li, Yan,Lan, Quan,Wang, Xi-Sheng
supporting information, p. 4806 - 4809 (2016/10/14)
The first example of copper-catalyzed decarboxylative atom transfer radical addition of alkynyl carboxylic acids has been developed with a readily available fluoroalkyl halide. This novel protocol has demonstrated a unique difunctionalization of nonterminal alkynes with a broad substrate scope and excellent functional-group tolerance. Mechanistic investigations revealed that the catalytic cycle was initiated by the attack of a difluoroalkyl radical to an in situ generated alkynylcopper species.
