956699-70-0Relevant academic research and scientific papers
Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety
Tomar,Bhattacharjee,Kamaluddin,Ashok Kumar
, p. 5321 - 5324 (2007)
Two new series of chalcones have been synthesized by reacting 1-(4-piperazin-1-yl-phenyl)ethanone and 1-(2,5-dichloro-3-thienyl)-1-ethanone with different substituted benzaldehydes in turn by Claisen-Schmidt condensation. The compounds have been character
Design, synthesis, biological evaluation, and molecular docking of chalcone derivatives as anti-inflammatory agents
Li, Jingfen,Li, Dong,Xu, Yiming,Guo, Zhenbo,Liu, Xu,Yang, Hua,Wu, Lichuan,Wang, Lisheng
, p. 602 - 606 (2017/01/17)
In this study, two series of 35 new chalcone derivatives containing aryl-piperazine or aryl-sulfonyl-piperazine fragment were synthesized and their structures were characterized by1H,13C and ESI-MS. The in vivo and in vitro anti-inflammatory activities of target compounds were evaluated by using classical para-xylene-induced mice ear-swelling model and ELISA assays. Furthermore, docking studies were performed in COX-2 (4PH9). The in vivo anti-inflammatory assays indicated that most of the target compounds showed significant anti-inflammatory activities. Docking results revealed that the anti-inflammatory activities of compounds correlated with their docking results. Especially, compound 6o exhibited the most potent anti-inflammatory activity in vivo with the lowest docking score of ?17.4?kcal/mol and could significantly inhibit the release of LPS-induced IL-6 and TNF-α in a dose-dependent manner in vitro.
Chalcone derivatives, and preparation method and application thereof
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, (2017/01/31)
The invention discloses chalcone derivatives, including aryl piperazidine and arylsulfonyl piperazidine matrine derivatives. The invention also discloses a preparation method of the derivatives and application of the derivatives in drugs.
Triarylpyridines: A versatile small molecule scaffold for G-quadruplex recognition
Waller, Zoe A. E.,Shirude, Pravin S.,Rodriguez, Raphael,Balasubramanian, Shankar
, p. 1467 - 1469 (2008/12/22)
The triarylpyridines are potent G-quadruplex ligands that are highly discriminating against duplex DNA and show promising selectivity between intramolecular quadruplexes. The Royal Society of Chemistry.
Antiproliferative activity of chalcones with basic functionalities
Liu, Xiaoling,Go, Mei-Lin
, p. 7021 - 7034 (2008/03/28)
A library of chalcones with different basic groups were synthesized and evaluated for antiproliferative activities against the human breast cancer (MCF 7) and colon cancer (HCT 116) cell lines. Structure-activity relationships were analyzed by projection
