957147-17-0

Basic information

• Product Name: 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide
• Synonyms: 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide
• CAS NO: 957147-17-0
• Molecular Weight: 487.64
• Mol File: 957147-17-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide(957147-17-0)
• EPA Substance Registry System: 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((trimethylsilyl)ethynyl)benzamide(957147-17-0)

Safety Data

• Hazardous Substances Data: 957147-17-0(Hazardous Substances Data)

Upstream product

• 89976-12-5 1-methyl-4-nitro-2-(trifluoromethyl) benzene 
• 694499-22-4 1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene 
• 320-37-6 4-nitro-2-(trifluoromethyl)benzoic acid 
• 859027-06-8 (4-nitro-2-(trifluoromethyl)phenyl)methanol 
• 82998-57-0 3-iodo-4-toluic acid 
• 52107-98-9 3-iodo-4-methylbenzoyl chloride 
• 694499-26-8 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 
• 90347-66-3 methyl 3-iodo-4-methylbenzoate 
• 943320-50-1 3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)benzamide 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 957147-18-1 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 
• 1421685-07-5 C₃₂H₃₁F₃N₆O 
• 1421685-06-4 C₃₀H₂₉F₃N₆O 
• 1421685-08-6 C₃₅H₃₁F₃N₆O 
• 1421685-09-7 C₃₀H₂₉F₃N₆O₂ 
• 1421684-97-0 C₃₀H₂₈F₃N₅O 
• 1421684-98-1 C₃₀H₂₉F₃N₆O 
• 1421684-99-2 3-([1,2,4]triazolo[1,5-a]pyrimidin-6-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)-phenyl)benzamide 
• 1431221-13-4 C₃₈H₄₅F₃N₆O₂Si 
• 1448705-58-5 C₃₆H₄₃F₃N₆O₂Si 
• 943319-70-8 ponatinib 

Relevant articles and documents

KINASE INHIBITORS AND USES THEREOF

This invention described herein relates to compounds of general formula (I) : (I), in which variable groups are as defined herein, and to their preparation and use. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases, such as Bcr-Abl kinase, and mutants thereof, such as the T315I mutant.

BCR-ABL kinase inhibitor and its application (by machine translation)

The present invention relates to the field of chemical medicines, in particular to compounds as represented by formula I having BCR-ABL kinase inhibitory activity, or pharmaceutically acceptable salt, isomer, solvate, crystal or prodrug thereof, and pharmaceutical composition containing the compounds, and application of the compounds or compositions in drug preparation. The compounds of the present invention have strong inhibitory effect on BCR-ABL kinase, and can be used to treat diseases such as tumors.

HETEROARYL ALKYNE COMPOUND AND APPLICATION THEREOF

The present invention belongs to the field of pharmaceutical chemistry. Specifically, the invention relates to compounds of general formula I having heteroaryl alkynyl moiety or pharmceutically acceptable salts, isomers, solvates, crystals or prodrugs the