95741-11-0Relevant academic research and scientific papers
Lithium alkoxide-promoted michael reaction between silyl enolates and α,β-unsaturated carbonyl compounds
Mukaiyama, Teruaki,Tozawa, Takashi,Fujisawa, Hidehiko
, p. 1410 - 1411 (2007/10/03)
Michael reaction between silyl enolates and α,β-unsaturated carbonyl compounds by using a catalytic amount of Lewis base such as lithium alkoxide in DMF proceeds smoothly to afford the corresponding Michael-adducts in good yields with moderate to high diastereoselectivities. This reaction can be reasonably explained by considering an alkoxide anion-initiated autocatalytic process.
Magnesium Chloride-Promoted Michael Addition of Dimethylsilyl Enolates to α-Enones
Miura, Katsukiyo,Nakagawa, Takahiro,Hosomi, Akira
, p. 2068 - 2070 (2007/10/03)
In the presence of MgCl2, dimethylsilyl (DMS) enolates 1 smoothly reacted with α-enones in DMF to form 1,5-diketones 3 in moderate to high yields. The Michael addition proceeded with moderate to high anti-diastereoselectivity.
Novel Reactive Silyl Enolates. Highly Stereoselective Aldol and Michael Reactions without Catalysts
Kobayashi, Shu,Nishio, Koichi
, p. 2647 - 2649 (2007/10/02)
Novel silyl enolates, prepared in situ from ketones and dimethylsilyl ditriflate (Me2Si(OTf)2) in the presence of a tertiary amine, reacted smoothly with electrophiles such as aldehydes, acetals, or α,β-unsaturated ketones without catalyst at -78 deg C to
New role of tin(II) compounds in organic synthesis
Mukaiyama, Teruaki,Kobayashi, Shu
, p. 39 - 52 (2007/10/02)
Three new carbon-carbon bond forming reactions by the use of new catalyst systems involving tin(II) compounds are described in this article.The aldol reaction of silyl enol ethers with acetals or aldehydes and the Michael reaction of silyl enol ethers wit
An Efficient and Extremly Mild Catalyst System, Combined Use of Trityl Chloride and Tin(II) Chloride, in the Aldol and Michael Reactions
Mukaiyama, Teruaki,Kobayashi, Shu,Tamura, Masanori,Sagawa, Yukihiro
, p. 491 - 494 (2007/10/02)
The aldol reaction of silyl enol ethers with acetals or aldehydes, and the Michael reaction of silyl enol ethrs with α,β-unsaturated ketones are efficiently catalyzed by the combined use of trityl chloride and tin(II) chloride under extremly mild conditio
