957470-88-1

Basic information

• Product Name: N,N-Diethyl-4'-methylbiphenyl-4-carboxamide
• Synonyms: N,N-Diethyl-4'-methylbiphenyl-4-carboxamide
• CAS NO: 957470-88-1
• Molecular Formula: C18H21NO
• Molecular Weight: 267
• Mol File: 957470-88-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 68-70℃
• Appearance: /
• CAS DataBase Reference: N,N-Diethyl-4'-methylbiphenyl-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Diethyl-4'-methylbiphenyl-4-carboxamide(957470-88-1)
• EPA Substance Registry System: N,N-Diethyl-4'-methylbiphenyl-4-carboxamide(957470-88-1)

Safety Data

• Hazardous Substances Data: 957470-88-1(Hazardous Substances Data)

Upstream product

• 4294-57-9 para-methylphenylmagnesium bromide 
• 10366-88-8 4-fluoro-N,N-diethyl-benzamide 
• 90252-89-4 p-tolylzinc(II) chloride 
• 7461-38-3 4-chloro-N,N-diethyl-benzamide 
• 5892-99-9 4-bromo-N,N-diethylbenzamide 
• 106-38-7 para-bromotoluene 

Relevant articles and documents

Nickel-catalyzed cross-coupling of aryl fluorides and organozinc reagents

Ni(PCy3)2Cl2 was demonstrated to effectively catalyze cross-coupling of aryl fluorides and organozinc reagents. Both electron-poor and -rich aryl fluorides can react effectively with nucleophiles including aryl-, methyl-, and benzylzinc chlorides. A wide range of substituents and functional groups are tolerated. In the presence of a directing group, PhC(O), the reaction is selective for cleavage of the C-F bond ortho to the carbonyl substituent in a difluoroarene.

P,N,N-Pincer nickel-catalyzed cross-coupling of aryl fluorides and chlorides

P,N,N-Pincer nickel complexes [Ni(Cl){N(2-R2PC6H 4)(2′-Me2NC6H4)}] (R = Ph, 3a; R = Pri, 3b; R = Cy, 3c) were synthesized and their catalysis toward the Kumada or Negishi cross-coupling reaction of aryl fluorides and chlorides was evaluated. Complex 3a effectively catalyzes the cross-coupling of (hetero)aryl fluorides with aryl Grignard reagents at room temperature. Complex 3a also catalyzes the cross-coupling of (hetero)aryl chlorides and arylzinc reagents at 80 °C with low catalyst loadings and good functional group compatibility. the Partner Organisations 2014.

Amido pincer nickel catalyzed kumada cross-coupling of aryl, heteroaryl, and vinyl chlorides

Amido pincer nickel complexes {Ni(Cl)[2-P(Ph2)C 6H4NC(Ph)=NAr]} (Ar = 4-MeC6H4, 1; Ar = 4-ClC6H4, 2; Ar = 4-MeOC6H4, 3) were shown to efficiently catalyze the cross-coupling of activated, unactivated, and deactivated aryl chlorides, N-heteroaryl chlorides, 1,4-dichlorobenzene, and vinyl chlorides with aryl Grignard reagents. Georg Thieme Verlag Stuttgart, New York.