95834-03-0Relevant articles and documents
Solid-phase synthesis of pyrazolines and isoxazolines with sodium benzenesulfinate as a traceless linker
Chen,Lam, Yulin,Lai, Yee-Hing
, p. 1067 - 1069 (2003)
(Matrix presented) The preparation of pyrazoline and isoxazoline derivatives with traceless solid-phase sulfone linker strategy is described. Key steps involved in the solid-phase synthetic procedure include (i) sulfinate S-alkylation, (ii) sulfone anion alkylation, (iii) γ-hydroxy sulfone → γ-ketosulfone oxidation, and (iv) traceless product release via elimination-cyclization. A library of 12 pyrazolines and isoxazolines was synthesized.