958357-86-3

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-3-IODO-5-BROMO-6-METHYLPYRIDINE is used as an intermediate in the synthesis of pharmaceuticals for its ability to interact with biological targets and enzymes. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
2-AMINO-3-IODO-5-BROMO-6-METHYLPYRIDINE is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective and targeted pesticides or other agricultural products.
Used in Medicinal Chemistry Research:
2-AMINO-3-IODO-5-BROMO-6-METHYLPYRIDINE is utilized in medicinal chemistry research for its potential to interact with biological targets and enzymes, providing a foundation for the discovery and development of novel therapeutic agents.

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 42753-71-9 5-bromo-6-methyl-pyridin-2-ylamine 

Downstream Products

• 958357-91-0 2-amino-5-bromo-6-methyl-3-(2-trimethylsilylethynyl)pyridine 
• 1609374-04-0 2-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine 
• 1609373-98-9 2-methylbenzofuran[2,3-b]pyridin-8-yl-trifluoromethanesulfonate 
• 958357-95-4 N-[5-bromo-6-methyl-3-(2-trimethylsilylethynyl)pyridin-2-yl]acetamide 
• 958358-00-4 5-bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine 

Relevant academic research and scientific papers

Synthesis method of nitrogen-containing deuterated methyl compound

The invention discloses a synthesis method of a nitrogen-containing deuterated methyl compound. The method comprises the following steps: 2-amino-6-methylpyridine used as an initial raw material reacts with an aprotic solution of N-bromosuccinimide, separation is performed to obtain a compound 1, the compound 1 is subjected to an iodination reaction, palladium catalysis, cyclization, hydroxyl trifluoromethanesulfonic acid anhydridization and a deuteration reaction, and then extraction, organic phase mixing, saturated salt water washing, drying, spin-drying, column separation and other post-treatments to obtain the final product. The raw material has a low cost and is easy to obtain, so compared with other synthesis routes, the synthesis method of the nitrogen-containing deuterated methyl compound has the advantages of obvious reduction of the cost, good separation effect, few impurities, suitableness for large-scale production, and increase of the demethylation synthesis yield; the deuterated product can be effectively obtained through method, the deuteration rate can reach 97%, the production temperature is not higher than 100 DEG C to easily achieve safe production, and the practical value is high.

INDOLE DERIVATIVES

The invention concerns indole derivatives of Formula (I) or pharmaceutically-acceptable salts thereof, wherein each of Ring A, m, R1, R2, n, R3 and G1 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.