959240-72-3

Basic information

• Product Name: 4-Bromo-2-methoxypyrimidine
• Synonyms: 4-Bromo-2-methoxypyrimidine;4-Bromo-2-methoxy-1,3-diazine
• CAS NO: 959240-72-3
• Molecular Formula: C₅H₅BrN₂O
• Molecular Weight: 189.01
• Product Categories: Building Blocks;Pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 959240-72-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 260℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.628
• Vapor Pressure: 0.0205mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.42±0.20(Predicted)
• CAS DataBase Reference: 4-Bromo-2-methoxypyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-methoxypyrimidine(959240-72-3)
• EPA Substance Registry System: 4-Bromo-2-methoxypyrimidine(959240-72-3)

Safety Data

• Hazardous Substances Data: 959240-72-3(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-methoxypyrimidine is a useful reactant for organic reactions and synthesis.

InChI:InChI=1/C5H5BrN2O/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3

Upstream product

• 3289-47-2 4-amino-2-methoxypyrimidine 
• 931-63-5 2-methoxypyrimidine 

Downstream Products

• 281233-16-7 methyl 4-(2-methoxypyrimidin-4-yl)benzoate 
• 1621525-51-6 4-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyrimidine 

Relevant articles and documents

A method for preparing 2, 4 - substituted pyrimidine

The invention belongs to the technical field of the synthesized compounds, in particular to a 2, 4 - substituted pyrimidine of the preparation method. The method comprises the following steps: 1) the 2 - substituted pyrimidine dissolved in tetrahydrofuran, in - 60 — - 78 °C lower dropping TMP.MgCl.LiCl, dropping 1 h after adding anhydrous zinc chloride, raising the temperature to room temperature, dropping halogen, 2 h after adding hydrochloric acid solution quenching reaction; 2) reaction of the reaction solution in order to ethyl acetate extraction, drying of the organic layer concentrated, column chromatography purification to obtain the product. The invention compared with the prior art, in order to 2 - substituted pyrimidines as raw materials can be specific selection 4 substituted, at the same time does not produce 5 substituted by-product, with good selectivity, single product, is easy to be purified, with mild reaction conditions, the reaction speed and the like.