959420-95-2

Upstream product

• 6103-22-6 5-hydroxymethyl-5-methyl-2-phenyl[1,3]dioxane 
• 920-46-7 Methacryloyl chloride 
• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Versatile synthesis of functional biodegradable polymers by combining ring-opening polymerization and postpolymerization modification via michael-type addition reaction

Various functional biodegradable polymers were readily prepared based on novel cyclic carbonate monomers, acryloyl carbonate (AC) and methacryloyl carbonate (MAC), by combining ring-opening polymerization (ROP) and Michael-type conjugate addition. AC and MAC monomers were synthesized in four straightforward steps from 1,1,1-tris(hydroxymethyl)ethane with good overall yields (ca. 40%). AC and MAC were able to copolymerize with ε-caprolactone (ε-CL) and D,L-lactide (LA) in toluene at 110°C using stannous octoate as a catalyst, yielding biodegradable copolymers with controlled (meth)acryloyl functional groups and molecular weights. The acryloyl groups were amenable to the Michaeltype conjugate addition with varying thiol-containing molecules such as 2-mercaptoethanol, 3-mercapto-propanoic acid, cysteamine, cysteine, and arginine-glycine-aspartic acid-cysteine (RGDC) peptide under mild conditions, to provide biodegradable materials with vastly different functionalities (e.g., hydroxyl, carboxyl, amine, amino acid, and peptides) and properties (e.g., hydrophilicity, cell adhesion). Notably, 100% functionalization was achieved with 2-mercaptoethanol, cysteamine and cysteine. Initial cell culture studies demonstrated enhanced cell adhesion and growth on films containing functional RGDC peptides as compared to those of the parent copolymer. Therefore, combination of ROP and Michael-type conjugate addition provides a versatile access to diverse types of functional biodegradable materials.

Polymeric depots for localization of agent to biological sites

Provided herein are polymeric particles and compounds and processes that can be used to prepare polymer-based particles and methods of using those particles to localize or concentrate a subsequently delivered agent to an in vivo site.

POLYMERIC DEPOTS FOR LOCALIZATION OF AN AGENT TO BIOLOGICAL SITES

no abstract published

Films and Particles

Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.