95957-92-9Relevant academic research and scientific papers
Cu-Catalyzed concise synthesis of pyridines and 2-(1 H)-pyridones from acetaldehydes and simple nitrogen donors
Li, Ziyuan,Huang, Xiaoqiang,Chen, Feng,Zhang, Chun,Wang, Xiaoyang,Jiao, Ning
supporting information, p. 584 - 587 (2015/03/04)
A highly selective copper-catalyzed concise synthesis of 3,5-diarylpyridine and 2-(1H)-pyridone has been achieved through cascade Chichibabin-type cyclization, C(sp3)-C(sp3) cleavage, and aerobic oxidation. Azide, ceric ammonium nitrate (CAN), and 2-aminopyridine are disclosed as efficient nitrogen donors in this Cu-catalysis using O2 as the oxidant. Water and molecular oxygen were employed as the oxygen source in the case of oxygenation.
Metal-free synthesis of substituted pyridines from aldehydes and NH4OAc under air
Yan, Rulong,Zhou, Xiaoqiang,Li, Ming,Li, Xiaoni,Kang, Xing,Liu, Xingxing,Huo, Xing,Huang, Guosheng
, p. 50369 - 50372 (2014/12/10)
A metal-free and efficient method for the synthesis of substituted pyridines with aldehydes and NH4OAc under mild conditions using air as the oxidant was developed. This oxidative cyclization process involves direct C-H bond functionalization, C-C/C-N bond formation and C-C bond cleavage.
A metal-free decarboxylative cyclization from natural α-amino acids to construct pyridine derivatives
Wang, Qiang,Wan, Changfeng,Gu, Yang,Zhang, Jintang,Gao, Lingfeng,Wang, Zhiyong
supporting information; experimental part, p. 578 - 581 (2011/05/06)
A metal-free decarboxylative cyclization from natural α-amino acids was developed and applied in the preparation of pyridine derivatives. By virtue of this method, a series of pyridines containing the moiety of natural α-amino acids can be synthesized efficiently from the corresponding natural α-amino acids. The Royal Society of Chemistry.
Use of the curtius rearrangement of acryloyl azides in the synthesis of 3,5-disubstituted pyridines: Mechanistic studies
Chuang, Ta-Hsien,Chen, Yu-Chi,Pola, Someshwar
experimental part, p. 6625 - 6630 (2010/11/18)
A series of disubstituted pyridine derivatives was synthesized from the corresponding acryloyl azides by acetic acid-promoted cycloaddition. This represents a novel and convenient synthetic approach to the symmetric 3,5-disubstituted pyridines. The nature of the substituent on the double bond and the utilized solvent were found to be crucial to the yield of pyridines. The reactivity of the acid-promoted cycloaddition increases with the presence of aryl groups, such as phenyl and pyridinyl. We also explored the comprehensive mechanism by the acid-promoted cycloaddition of 13C-labeled cinnamoyl azide. The symmetric 3,5-disubstituted pyridines were synthesized from acryloyl azides by acetic acid-promoted trimolecular condensation.
