26829-64-1

Upstream product

• 102-92-1 cinnamoyl chloride 
• 104-55-2 3-phenyl-propenal 
• 621-82-9 Cinnamic acid 
• 26112-94-7 1-(3-phenylpropenoyl)-1H-benzotriazole 
• 108761-28-0 (carbonic acid ethyl ester)-cinnamic acid-anhydride 
• 3538-69-0 (E)-3-phenylacryloylhydrazide 
• 140-10-3 (E)-3-phenylacrylic acid 
• 71721-74-9 trans-Zimtsaeure-p-nitrophenylester 
• 62222-44-0 m-nitrophenyl cinnamate 
• 73789-33-0 3,4-dinitrophenyl cinnamate 
• 541-41-3 chloroformic acid ethyl ester 
• 14371-10-9 (E)-3-phenylpropenal 
• 100-52-7 benzaldehyde 
• 328012-09-5 (E)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-phenylprop-2-en-1-one 

Downstream Products

• 4737-20-6 cinnamoyl isocyanate 
• 74088-05-4 N,N'-distyryl-urea 
• 621-79-4 cinnamamide 
• 1005793-82-7 N-Acetylzimtsaeureamid 
• 115601-07-5 N,N-Diacetyl-zimtsaeureamid 
• 7664-41-7 ammonia 
• 621-82-9 Cinnamic acid 
• 621-79-4 cinnamamide 
• 1222833-08-0 C₁₅H₁₂N₄O 
• 33066-20-5 (E)-1-isocyanato-2-phenylethene 
• 102-93-2 3-phenylpropionamide 
• 140-10-3 (E)-3-phenylacrylic acid 
• 877-95-2 methyl-N-(benzyl-methyl)-formamide 
• 92581-12-9 4-trans-styryl-hepta-1,6-dien-4-ol 

Relevant academic research and scientific papers

Iodine(V) reagents in organic synthesis. Dess-Martin periodinane mediated efficient one-pot oxidation of aldehydes to acyl azides

A mild, efficient and general method for the one-step preparation of acyl azides from aldehydes using Dess-Martin periodinane and sodium azide is described.

Oxidation of aldehydes to acyl azides using triazidochlorosilane (TACS)-active manganese dioxide reagent

Triazidochlorosilane (TACS)-active manganese dioxide is a new and versatile system for the efficient oxidation of aldehydes to the corresponding acyl azides at 0°C, in dichloromethane.

Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction

A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.

Suppressive activities of KC1–3 on HMGB1-mediated septic responses

In the present study, several decursin analogues (KC1–3) were synthesized and evaluated in terms of their anti-septic activities on high mobility group box 1 (HMGB1)-mediated septic responses and survival rate in a mouse model of sepsis. KC1 and KC3, but not KC2, significantly reduced HMGB1 release in lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs) and attenuated the cecal ligation and puncture (CLP)-induced release of HMGB1. Additionally, in vitro analyses revealed that KC1 and KC3 both alleviated HMGB1-mediated vascular disruptions and inhibited hyperpermeability in mice, and in vivo analyses revealed that KC1 and KC3 reduced sepsis-related mortality and tissue injury. Taken together, the present results suggest that KC1 and KC3 both reduced HMGB1 release and septic mortality and, thus, may be useful for the treatment of sepsis.

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

Chikungunya virus is a re-emerging arbovirus transmitted to humans by Aedes mosquitoes, responsible for an acute febrile illness associated with painful and debilitating arthralgia, which can persist for several months or become chronic. Over the past few years, infection with this virus has spread worldwide with a previously unknown virulence. No specific antiviral treatments nor vaccines are currently available against this important pathogen. Starting from the structure of a class of selective anti-CHIKV agents previously identified in our research group, different modifications to this scaffold were rationally designed, and 69 novel small-molecule derivatives were synthesised and evaluated for their inhibition of Chikungunya virus replication in Vero cells. Further structure-activity relationships associated with this class of antiviral agents were elucidated for the original scaffolds, and novel antiviral compounds with EC50 values in the low micromolar range were identified. This work provides the foundation for further investigation of these new structures as antivirals against Chikungunya virus.

Chiral phosphoric acid catalyzed enantioselective annulation of acyclic enecarbamates to: In situ -generated ortho -quinone methides

The first organocatalytic asymmetric reaction of acyclic enecarbamates with o-quinone methides is disclosed. BINOL-based phosphoric acid catalysts were found to be suitable for the annulation reaction. With 10 mol% of the TRIP catalyst, high yields as well as excellent diastereo- and enantioselectivities are achieved for a variety of 2,3,4-trisubstituted chroman products.

Decursinol-carbamate derivatives, and pharmaceutical composition containing the same for preventing or treating cancer

The present invention relates to a decursinol carbamate derivative represented by chemical formula 1, and to a composition for preventing or treating cancer containing the same. The decursinol carbamate derivative shows excellent activity of inhibiting a

Visible light C-H amidation of heteroarenes with benzoyl azides

Benzoyl azides were used for the direct and atom economic C-H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroaryl- or alkenyl acyl azides and has a wide scope for heteroarenes, including pyrroles, indole, furan, benzofuran and thiophene giving good regio-selectivities and yields.

Thermal-induced dimerization cyclization of ethyl N-(styrylcarbamoyl) acetates: Formation of 4-hydroxy-2(1H)-pyridone-3- carboxamide derivatives

Thermal-induced dimerization cyclization of ethyl N-(styrylcarbamoyl) acetate derivatives has been investigated, leading to 4-hydroxy-2(1H)-pyridone- 3-carboxamide derivatives with good yields in diphenyl ether on 200-210 °C. Ethyl N-(styrylcarbamoyl)acet

Synthesis of styryl substituted semicarbazides under microwave irradiation

A series of styryl substituted semicarbazides were synthesised by reaction of trans-styryl isocyanate, prepared by Curtius rearrangement of cinnamoyl azide, with acid hydrazides under microwave irradiation using a one-pot procedure. The effects of microwa