959632-18-9

Upstream product

• 149104-89-2 4-bromo-3-methylbenzylalcohol 
• 52107-87-6 4-iodo-3-methylbenzoic acid 

Downstream Products

• 1453498-94-6 4-benzyloxy-1-{2-[4-(3-hydroxy-azetidin-1-ylmethyl)-2-methyl-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one 
• 1453499-05-2 4-benzyloxy-1-{2-[4-(3-hydroxy-3-methyl-pyrrolidin-1-ylmethyl )-2-methyl-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one 
• 1453499-96-1 2-bromo-1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone 
• 1453499-97-2 4-benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one 
• 1453499-98-3 4-benzyloxy-1-[2-(4-{bromomethyl}-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one 
• 1453499-95-0 1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone 
• 1453499-06-3 (S)-4-(benzyloxy)-1-(2-(4-((3-hydroxypyrrolidin-1-yl)methyl)-2-methylphenyl)-2-oxoethyl)pyridin-2(1H)-one 
• 1453500-10-1 2-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-5-(5-chloro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one 
• 1453500-12-3 2-[2-(4-bromomethyl-2-methylphenyl)-2-oxo-ethyl]-5-(5-bromo8bpyridin-2-ylmethoxy)-2H-pyridazin-3-one 
• 1453500-16-7 2-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one 
• 1453499-36-9 4-(5-bromo-pyridin-2-ylmethoxy)-1-[2-(4-dimethylaminomethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one 
• 1453499-18-7 1-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-4-((5-fluoropyridin-2-yl)methoxy)pyridin-2(1H)-one 
• 1453500-46-3 1-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-4-((5-methoxypyridin-2-yl)methoxy)pyridin-2(1H)-one 
• 1453499-58-5 5-(benzyloxy)-2-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)pyridazin-3(2H)-one 

Relevant academic research and scientific papers

Design, synthesis and evaluation of MCH receptor 1 antagonists - Part III: Discovery of pre-clinical development candidate BI 186908

Abstract Although overweight and obesity are highly prevalent conditions, options to treat them are still very limited. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, two series of pyridones and pyridazinones

COMPOUNDS AND METHODS FOR MODULATING FXR

Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.