959979-04-5Relevant articles and documents
Enantioselective Pictet-Spengler-type cyclizations of hydroxylactams: H-bond donor catalysis by anion binding
Raheem, Izzat T.,Thiara, Parvinder S.,Peterson, Emily A.,Jacobsen, Eric N.
, p. 13404 - 13405 (2007)
Highly enantioenriched indolizinone and quinolizinone products are obtained in the thiourea-catalyzed cyclization of tryptamine-derived hydroxylactams. Substituent and counterion effect studies point to a novel mechanism of catalysis involving rate-limiti