959997-88-7 Usage
Uses
Used in Organic Synthesis:
2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the introduction of trifluoromethyl and bromo substituents into target molecules, enabling the development of new chemical entities with potential applications in various fields.
Used in Medicinal Chemistry and Drug Discovery:
In the pharmaceutical industry, 2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID is used as a reagent in chemical reactions, particularly in Suzuki-Miyaura cross-coupling reactions. This reaction is a powerful method for the formation of carbon-carbon bonds, allowing for the efficient synthesis of complex molecules with potential therapeutic properties. The introduction of trifluoromethyl and bromo groups can significantly impact the pharmacokinetic and pharmacodynamic properties of drug candidates, making 2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID an essential tool in the discovery and development of new medicines.
Used in Chemical Libraries for Drug Screening:
2-BROMO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID is used as a key component in the creation of diverse chemical libraries for drug screening. The ability to introduce trifluoromethyl and bromo substituents into organic molecules allows for the exploration of a wide range of chemical space, increasing the chances of identifying novel and potent drug candidates with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 959997-88-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,9,9,9 and 7 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 959997-88:
(8*9)+(7*5)+(6*9)+(5*9)+(4*9)+(3*7)+(2*8)+(1*8)=287
287 % 10 = 7
So 959997-88-7 is a valid CAS Registry Number.
959997-88-7Relevant academic research and scientific papers
Use of 2-bromophenylboronic esters as benzyne precursors in the Pd-catalyzed synthesis of triphenylenes
Garcia-Lopez, Jose-Antonio,Greaney, Michael F.
supporting information, p. 2338 - 2341 (2014/05/20)
ortho-Substituted aryl boronates are introduced as aryne precursors for transition-metal-catalyzed transformations. On treatment with tBuOK and Pd(0), metal-bound aryne intermediates are formed that undergo effective trimerization to form useful triphenylene compounds. For meta-substituted arynes, the 3:1 product ratio in favor of non-C3 symmetric material is indicative of a benzyne mechanism.
