96009-71-1

Upstream product

• 52200-90-5 4-amino-2-methoxyphenol 
• 108-95-2 phenol 
• 100-02-7 4-nitro-phenol 
• 99-53-6 2-methyl-4-nitrophenol 
• 78265-45-9 2-chloro-6-methoxy-4-nitro-phenol 

Downstream Products

• 1268490-52-3 3-chloro-4-[(6-chloro-4-pyrimidinyl)oxy]-5-(methoxy)aniline 

Relevant academic research and scientific papers

Synthesis method of 2-amino-4-chloro-6-metoxyphenol

The invention discloses a synthesis method of 2-amino-4-chloro-6-metoxyphenol, which belongs to the field of chemical synthesis. The method comprises the following steps of adding p-nitrophenol of nitrosonitric acid and sulfuric acid into phenol, adding methane chloride and anhydrous glacial acetic acid to obtain a mixture, then putting the mixture into a high-pressure autoclave, adding absolute ethyl alcohol and inputting hydrogen, performing pumping filtration to obtain filter residues after reaction, adding copper chloride into the filter residues, generating light green precipitation after adjusting pH through sodium hydroxide, filtering, washing the filter residues and drying to obtain the 2-amino-4-chloro-6-metoxyphenol.

COMPOUNDS AND METHODS

Disclosed are compounds having the formula: wherein R1 and R2 are as defined herein, and methods of making and using the same.