96013-53-5

Basic information

• Product Name: 1-(toluene-4-sulfonyl)-1,5-dihydropyrrol-2-one
• Synonyms: 1-(toluene-4-sulfonyl)-1,5-dihydropyrrol-2-one
• CAS NO: 96013-53-5
• Molecular Weight: 237.279
• Mol File: 96013-53-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(toluene-4-sulfonyl)-1,5-dihydropyrrol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(toluene-4-sulfonyl)-1,5-dihydropyrrol-2-one(96013-53-5)
• EPA Substance Registry System: 1-(toluene-4-sulfonyl)-1,5-dihydropyrrol-2-one(96013-53-5)

Safety Data

• Hazardous Substances Data: 96013-53-5(Hazardous Substances Data)

Upstream product

• 10019-95-1 N-tosylpyrrolidinone 
• 1252614-25-7 N-(p-toluenesulfonyl)-3-(phenylselanyl)-pyrrolidin-2-one 
• 17639-64-4 N-p-toluenesulfonylpyrrole 
• 847806-13-7 S-ethyl-S-ethenyl-N-(toluene-4-sulfonyl)sulfilimine 
• 127-65-1 chloroamine-T 
• 847806-04-6 3,3-dichloro-5-ethylthio-1-(toluene-4-sulfonyl)pyrrolidin-2-one 
• 847806-05-7 5-ethylthio-1-(toluene-4-sulfonyl)pyrrolidin-2-one 

Downstream Products

• 1514833-12-5 (R)-4-(dimethyl(phenyl)silyl)-1-tosyl-1,5-dihydro-2H-pyrrolidin-2-one 
• 1373152-62-5 methyl 4-oxo-1-phenyl-5-tosyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 1373152-41-0 methyl 6-oxo-1-phenyl-5-tosyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 1373152-64-7 methyl 1-(4-methoxyphenyl)-4-oxo-5-tosyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 1373152-63-6 methyl 1-(4-methoxyphenyl)-6-oxo-5-tosyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 96013-54-6 4-methyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-one 

Relevant articles and documents

Platinum-Catalyzed Desaturation of Lactams, Ketones, and Lactones

The development of a general platinum-catalyzed desaturation of N-protected lactams, ketones, and lactones to their conjugated α,β-unsaturated counterparts is reported. The reaction operates under mildly acidic conditions at room temperature or 50 °C. It is scalable and tolerates a wide range of functional groups. The complementary reactivity to the palladium-catalyzed desaturation is demonstrated in the efficient conversion of iodide, bromide, and sulfur-containing substrates.

A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies

Here we propose a novel one-pot synthesis of new tosyl-pyrrole derivatives. By means of the new developed method, pyrrole derivatives were synthesized at room temperature in a single step, and a useful method is proposed for the synthesis of similar compounds. Moreover, inhibitions of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II by 1-tosyl-pyrrole and 1-tosyl-pyrrol-2-on derivatives were investigated. 1-Tosyl-pyrrole, 1-tosyl-1H-pyrrol-2(5H)-one, 5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one and 5-oxo-1-tosyl-2,5-dihydro-1H-pyrrol-2-yl acetate showed inhibitory action with Ki values in the range of 14.6-42.4 μM for hCA I and 0.53-37.5 μM for hCA II, respectively. All pyrrole derivatives were competitive inhibitors with 4-nitrophenylacetate as substrate. Some new synthesized pyrrole derivatives showed very effective hCA II inhibitory effects, in the same range as the clinically used sulfonamide acetazolamide, and might be used as leads for generating enzyme inhibitors targeting other CA isoforms.

A new synthesis of γ-lactams based on the reaction of vinyl sulfilimines with dichloroketene

(Chemical Equation Presented) The reactions of several aryl-, furanyl-, and vinyl substituted sulfilimines with dichloroketene proceeded at 25°C to yield thioalkyl substituted γ-lactams which, in turn, were converted to a variety of nitrogen-containing substrates.