96022-77-4

Usage

Uses

Used in Organic Synthesis:
2-Chloro-6-methoxy-7-deazapurine is used as an intermediate in organic synthesis for the development of various chemical compounds. Its unique structure allows it to be a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-6-methoxy-7-deazapurine is used as a key intermediate in the synthesis of novel drug candidates. Its unique chemical properties enable the development of new therapeutic agents with potential applications in various disease areas, including oncology, infectious diseases, and inflammatory disorders.
Used in Research and Development:
2-Chloro-6-methoxy-7-deazapurine is also used in research and development settings to study the structure-activity relationships of purine analogs and to explore their potential as therapeutic agents. Its synthesis and modification can provide valuable insights into the design and optimization of new drugs with improved efficacy and safety profiles.

Upstream product

• 124-41-4 sodium methylate 
• 90213-66-4 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 67-56-1 methanol 
• 934524-10-4 2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine 

Relevant academic research and scientific papers

NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS

Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

Synthesis and biological evaluation of 2-anilino-4-substituted-7H- pyrrolopyrimidines as PDK1 inhibitors

PDK1, a biological target that has attracted a large amount of attention recently, is responsible for the positive regulation of the PI3K/Akt pathway that is often activated in a large number of human cancers. A series of second-generation 2-anilino-4-substituted-7H-pyrrolopyrimidines were synthesised by installation of various functions at the 4-position of the 7H-pyrrolopyrimidine scaffold. All compounds were screened against the isolated PDK1 enzyme and dose response analysis was obtained on the best compounds of the series. Crown Copyright

7-Deaza Isosters of 2'-Deoxyxanthosine and 2'-Deoxyspongosine - Synthesis via Glycosylation of 2,4-Dichloro-7H-pyrrolopyrimidine

7-Deaza-2'-deoxyxanthosine (1a) and 7-deaza-2'-deoxyspongosine (2), two new pyrrolopyrimidine deoxynucleosides, have been prepared by nucleophilic displacement of the chloro substituents of the intermediate 2,4-dichloro-7-2-deoxy-3,5-di-O-(p-toluo