960249-81-4

Basic information

• Product Name: 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol
• Synonyms: 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol
• CAS NO: 960249-81-4
• Molecular Weight: 276.302
• Mol File: 960249-81-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol(960249-81-4)
• EPA Substance Registry System: 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol(960249-81-4)

Safety Data

• Hazardous Substances Data: 960249-81-4(Hazardous Substances Data)

Upstream product

• 960249-70-1 [2-(trifluoromethyl)-2-oxiranyl]methyl 4-methylbenzenesulfonate 
• 14321-27-8 N-ethylbenzylamine 

Downstream Products

• 960249-82-5 5-amino-N-(2-{[ethyl(phenylmethyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide 
• 960249-80-3 5-amino-N-{2-[(ethylamino)methyl]-3,3,3-trifluoro-2-hydroxypropyl}-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide 

Relevant articles and documents

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition

The synthesis and in vitro properties of six analogues of the selective glucocorticoid receptor (GR) agonist GSK866, bearing a warhead for covalent linkage to the glucocorticoid receptor, is described.

NOVEL COMPOUNDS

The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.