960249-80-3

Upstream product

• 960249-75-6 5-amino-1-(4-fluorophenyl)-N-((2-(trifluoromethyl)-2-oxiranyl)methyl)-1H-pyrazole-4-carboxamide 
• 75-04-7 ethylamine 
• 960249-82-5 5-amino-N-(2-{[ethyl(phenylmethyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide 
• 187949-90-2 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid 
• 138907-68-3 ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate 
• 960249-81-4 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol 
• 960249-73-4 5-amino-1-(4-fluorophenyl)-N-(3,3,3-trifluoro-2-hydroxy-2-(hydroxymethyl)propyl)-1H-pyrazole-4-carboxamide 
• 960249-74-5 2-((([5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl 4-methylbenzenesulfonate 

Downstream Products

• 1034141-34-8 5-amino-N-(2-(ethyl((2,3-difluorophenylcarbonyl)amino)methyl)-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide 

Relevant academic research and scientific papers

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition

The synthesis and in vitro properties of six analogues of the selective glucocorticoid receptor (GR) agonist GSK866, bearing a warhead for covalent linkage to the glucocorticoid receptor, is described.

PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS

The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation.

NOVEL COMPOUNDS

The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.