96027-74-6

Usage

Uses

Used in Pharmaceutical Industry:
Desethyl Amiodarone Hydrochloride is used as a reference standard for the development and validation of analytical methods in the pharmaceutical industry. It helps in ensuring the quality, purity, and potency of Amiodarone-containing products.
Used in Clinical Laboratories:
Desethyl Amiodarone Hydrochloride is used as a spiking solution in therapeutic drug monitoring analyses by HPLC or LCMS. It aids in the accurate measurement of Amiodarone levels in patients, helping healthcare professionals to monitor and adjust dosages to maintain the drug's therapeutic range.
Used in Research and Development:
Desethyl Amiodarone Hydrochloride is used as a research tool in the study of ion channel blockers and their effects on cardiac arrhythmias. It contributes to the understanding of the mechanisms of action and potential applications of Amiodarone and its metabolites in the treatment of various cardiac conditions.

InChI:InChI=1/C23H25I2NO3.ClH/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2;/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3;1H

Upstream product

• 1096359-59-9 {4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone 
• 4535-87-9 N-(2-chloroethyl)ethylamine hydrochloride 
• 1951-26-4 2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran 

Relevant academic research and scientific papers

Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives

The aim of this work was to compare hepatocellular toxicity and pharmacological activity of amiodarone (2-n-butyl-3-[3,5 diiodo-4- diethylaminoethoxybenzoyl]-benzofuran; B2-O-Et-N-diethyl) and of eight amiodarone derivatives. Three amiodarone metabolites

Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites

Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines. Several of these amiodarone derivatives act as specific agonists of the G protein-coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1). This result demonstrates a novel molecular target for amiodarone derivatives with potential clinical significance.

Pharmaceutical and veterinary compositions for the treatment of ischemic cardiac disorders

Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: STR1 or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X1 and X2 represent hydrogen or iodine with the proviso that when R represents diethylamino X1 and X2 are different. These compositions are useful for the treatment of ischemic cardiac disorders.