960356-44-9

Upstream product

• 144701-48-4 telmisatran 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 528560-93-2 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester 
• 144702-27-2 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl 

Downstream Products

• 144701-48-4 telmisatran 

Relevant academic research and scientific papers

4 ′ - [[2 a-n - (1 - methylbenzimidazole -2 - yl) - benzimidazole -1 - yl methyl propyl -4 - -6 -] - methyl] - biphenyl carboxylic acid ammonium salt crystals -2 - (by machine translation)

PROBLEM TO BE SOLVED: To provide a method for obtaining 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazole-1-yl]-methyl]-biphenyl-2-carboxylic acid with high purity.SOLUTION: A method for purifying a compound of formula (1) below includes: a dissolution process of dissolving a crude substance of 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazole-1-yl]-methyl]-biphenyl-2-carboxylic acid in a mixed solvent of water and a 2-12C alcohol by adding 2.0 to 30.0 mol of ammonia per mol of a composition of formula (1) below; a crystallization process of depositing an ammonium salt of the composition of formula (1) below by discharging ammonia from the solvent obtained in the process; and a process of separating and drying the ammonium salt.

METHOD FOR PRODUCING AMMONIUM SALT OF TELMISARTAN

PROBLEM TO BE SOLVED: To provide a method for producing an ammonium salt of telmisartan effective as a hypotensive agent with high purity. SOLUTION: The method for producing an ammonium salt of telmisartan comprises a dissolution step of dissolving a crude body of telmisartan by adding, in a mixed solvent of water, a 2-12C alcohol and ethyl acetate, ammonia in an amount of 2.0 to 30.0 mol based on 1 mol of the telmisartan at 0 to 30°C to form an ammonium salt of telmisartan and a crystallization step of depositing the ammonium salt of telmisartan from the solution produced in the dissolution step at 0 to 30°C and achieves reduction of specific impurities C and D. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Telmisartan ammonium salt crystal form and preparation method thereof

The invention provides a telmisartan ammonium salt crystal form and a preparation method thereof.A CuKa ray of the telmisartan ammonium salt crystal form serves as a feature X-ray to be used for powder measurement, the map of the telmisartan ammonium salt

PREPARATION OF TELMISARTAN SALTS

New salts of telmisartan, in amorphous and crystalline forms, together with two new polymorphic forms of telmisartan potassium, have been prepared by crystallization, evaporation of solvent, spray-drying or lyophilization and were included into a pharmaceutical formulation.