960388-66-3

Upstream product

• 960388-62-9 1-(3-bromophenyl)-1-pyridin-4-ylmethanamine 
• 96989-50-3 di-2-pyridyl thionocarbonate 
• 108-36-1 1,3-dibromobenzene 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 100-48-1 pyridine-4-carbonitrile 
• 1659-31-0 2,2'-dipyridyl carbonate 

Downstream Products

• 960388-72-1 4-(3-bromo-phenyl)-4-pyridin-4-yl-thiazolidine-2,5-dithione 
• 960388-78-7 8-(3-Bromophenyl)-8-pyridin-4-yl-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960388-95-8 8-(3-bromo-phenyl)-8-pyridin-4-yl-2,3,4,8-tetrahydro-imidazo[1,5-a]pyrimidin-6-ylamine 
• 960389-49-5 8-(3-bromophenyl)-3,3-difluoro-8-(pyridin-4-yl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidine-6-amine 
• 960389-39-3 (4S)-8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-4-carboxylic acid 
• 960389-37-1 N-[8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-yl]methanesulfonamide 
• 960389-25-7 8-(3-bromophenyl)-8-(4-methoxyphenyl)-3-(methylsulfonyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-33-7 methyl 8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-carboxylate 
• 960389-41-7 8-(3-bromophenyl)-3,3-difluoro-8-(4-methoxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-31-5 8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-carbonitrile 
• 960389-27-9 8-(3-bromophenyl)-3-hydroxy-8-(4-methoxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-29-1 8-(3-bromophenyl)-3-methoxy-8-(4-methoxyphenyl)-3,4,7,8-tetrahydroimidazo[1,5-a]pyrimidine-6(2H)-thione 
• 960389-45-1 8-(3-bromophenyl)-8-(4-methoxyphenyl)-3-(methylsulfonyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidine-6-amine 
• 960388-68-5 4-(3-bromophenyl)-4-(4-methoxyphenyl)-1,3-thiazolidine-2,5-dithione 

Relevant academic research and scientific papers

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

The evaluation of a series of bicyclic aminoimidazoles as potent BACE-1 inhibitors is described. The crystal structures of compounds 14 and 23 in complex with BACE-1 reveal hydrogen bond interactions with the protein important for achieving potent inhibit

AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA

This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Di

AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA

This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

AMINO- IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT. ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA.

This invention relates to novel compounds having the structural formula I below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

New Compounds 319

This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.