960389-49-5Relevant academic research and scientific papers
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Swahn, Britt-Marie,Holenz, J?rg,Kihlstr?m, Jacob,Kolmodin, Karin,Lindstr?m, Johan,Plobeck, Niklas,Rotticci, Didier,Sehgelmeble, Fernando,Sundstr?m, Marie,F?lting, Johanna,Georgievska, Biljana,Gustavsson, Susanne,Neelissen, Jan,Ek, Margareta,Olsson, Lise-Lotte,Berg, Stefan,Berg, Stefan Von
, p. 1854 - 1859 (2012/04/17)
The evaluation of a series of bicyclic aminoimidazoles as potent BACE-1 inhibitors is described. The crystal structures of compounds 14 and 23 in complex with BACE-1 reveal hydrogen bond interactions with the protein important for achieving potent inhibit
AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA
-
, (2008/06/13)
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
New Compounds 319
-
Page/Page column 28, (2008/06/13)
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
AMINO- IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT. ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA.
-
Page/Page column 53-54, (2008/06/13)
This invention relates to novel compounds having the structural formula I below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
