96102-26-0Relevant academic research and scientific papers
Polarity Sensitive Bioorthogonally Applicable Far-Red Emitting Labels for Postsynthetic Nucleic Acid Labeling by Copper-Catalyzed and Copper-Free Cycloaddition
E?rd?gh, ádám,Steinmeyer, Jeannine,Peewasan, Krisana,Schepers, Ute,Wagenknecht, Hans-Achim,Kele, Péter
, p. 457 - 464 (2016/03/05)
Two series of new, water-soluble, membrane-permeable, far-red/NIR emitting benzothiazolium-based fluorescent labels with large Stokes' shifts were synthesized that can be conjugated to alkyne-modified biomolecules through their azide moiety via azide-alky
Functionalization of mono- and oligonucleotides with phosphane ligands by amide bond formation
Nuzzolo, Marzia,Grabulosa, Arnald,Slawin, Alexandra M. Z.,Meeuwenoord, Nico J.,Van Der Marel, Gijsbert A.,Kamer, Paul C. J.
experimental part, p. 3229 - 3236 (2010/08/20)
Seven phosphane-functionalized deoxyuridines have been prepared by amide bond formation between aminodeoxyuridines and phosphanylcarboxylic acids. X-ray crystal structures for two of these new modified nucleosides have been obtained. The same coupling method has been extended to oligonucleotides. The phosphane containing strands have been purified and characterized by MALDI-TOF and, for the first time, 31P NMR spectrometry. Coordination of a phosphane-modified 15-mer to a [PdCl(η3-allyl)] moiety has been confirmed by 31P NMR spectroscopy.
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
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, (2008/06/13)
Replacement of the natural nucleotides with unnatural zwitterionic nucleotides having a cationic moiety tethered to the base (or analog thereof) results in oligodeoxynucleotides with diminished charge but undiminished ability to complex with DNA at low io
