120016-97-9

Upstream product

• 14719-21-2 trifluoroacetyl-propargyl amine 
• 104375-88-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 115899-40-6 2,2,2-trifluoro-N-(3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-yn-1-yl)acetamide 
• 54-42-2 5-Iodo-2'-deoxyuridine 

Downstream Products

• 244285-86-7 3'-O-acetyl-5-(3''-trifluoroacetamidopropynyl)-5'-O-dimethoxytrityl-2'-deoxyuridine 
• 120016-98-0 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-3'-[(2-cyano-ethyl)-N,N-diisopropylaminophosphoramidite] 
• 179101-49-6 5-(3-amino-1-propynyl)-2'-deoxyuridine 5'-triphosphate 
• 339569-43-6 5-(3-aminopropynyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 
• 96102-26-0 5-[3-N-(trifluoroacetyl)aminopropyl]-5'-O-(4,4'-dimethyltrityl)-2'deoxyuridine 

Relevant academic research and scientific papers

OLIGONUCLEOTIDE LABELLING: A CONCISE SYNTHESIS OF A MODIFIED THYMIDINE PHOSPHORAMIDITE

The condensation of 5'-dimethoxytrityl-5-iodo-2'-deoxyuridine (1) with N-trifluoroacetylpropargylamine (2) in the presence bis(triphenylphosphine) Pd(II) chloride and copper(I) iodide and subsequent conversion to the 3'-phosphoramidite (4) is an efficient

A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing

A new DNA building block (dTetU) bearing a tetrazole and allyloxy group at N-phenyl ring linked through an aminopropynyl linker to the 5-position of 2′-deoxyuridine was synthesized. The modified DNA can be lit up via a photoinduced intramolecul

Functionalization of mono- and oligonucleotides with phosphane ligands by amide bond formation

Seven phosphane-functionalized deoxyuridines have been prepared by amide bond formation between aminodeoxyuridines and phosphanylcarboxylic acids. X-ray crystal structures for two of these new modified nucleosides have been obtained. The same coupling method has been extended to oligonucleotides. The phosphane containing strands have been purified and characterized by MALDI-TOF and, for the first time, 31P NMR spectrometry. Coordination of a phosphane-modified 15-mer to a [PdCl(η3-allyl)] moiety has been confirmed by 31P NMR spectroscopy.

STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES

The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quenc

Building-block approach for the straightforward incorporation of a new FRET (fluorescence-resonance-energy transfer) system into synthetic DNA

The synthesis of the two new phosphoramidites 5 and 8 bearing a carbostyril (= quinolin-2(1H)-one) chromophore used as donor entity in our recently developed new FRET (fluorescence-resonance-energy transfer) system is described (Schemes 1 and 2) The high

DNA minicircles with gaps for versatile functionalization

(Figure Presented) Doing the rounds: A highly straightforward approach has been developed that provides access to DNA minicircles containing a 21-mer single-stranded gap region of defined sequence (see picture). The single-stranded domain within a small c

Application of a highly robust and efficient fluorescence-resonance-energy- transfer (FRET) system in DNA

We report a feasibility study for the application of our newly developed highly efficient and robust fluorescence-resonance-energy-transfer (FRET) system to DNA. A 2′-oligodeoxynucleotide, 12, equipped with a quinolinone derivative as donor and a (bathoph

Quantitative analysis of receptors for adenosine nucleotides obtained via in vitro selection from a library incorporating a cationic nucleotide analog

5-(3″-Aminopropynyl)-2′-deoxyuridine (dJ), a modified nucleoside with a side chain carrying a cationic functional group, was incorporated into an oligonucleotide library, which was amplified using the Vent DNA polymerase in a polymerase chain reaction (PC