96125-56-3Relevant academic research and scientific papers
Process for preparing 1,5-benzothiazepine derivatives
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, (2008/06/13)
This disclosure describes a process for the preparation of 1,5-benzothiazepinone derivatives. The process involves the use of sulfonic acids as catalysts to effect ring closure to form the 1,5-benzothiazepinone ring. The resulting compounds have well known pharmaceutical properties.
Process for preparing 1,5-benzothiazepine derivatives
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, (2008/06/13)
There is disclosed a process for preparing 1,5-benzothiazepine derivatives represented by the formula: STR1 wherein one of R1 and R2 is a lower alkyl group or halogen atom, and the other is hydrogen atom, R3 is a lower alkyl group or a lower alkoxy group, which comprises subjecting a propionic acid compound represented by the formula (II): STR2 wherein R1, R2 and R3 have the same meanings as defined above, and R4 represents hydrogen atom or an ester residue, to intramolecular ring closing reaction in the presence of a sulfonic acid compound represented by the formula (III): wherein R5 represents a lower alkyl group or a substituted or unsubstituted phenyl group.
1,5-benzothiazepine derivatives and processes for preparing the same
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, (2008/06/13)
Novel 1,5-benzothiazepine derivatives of the formula: STR1 wherein R 1 is hydrogen or lower alkyl, R 2 is hydrogen, lower alkanoyl or benzyl, R 3 is hydrogen or lower alkyl and either one of R 4 and R 5 is hydrogen and the other is chlorine, or a pharmace
8-Chloro-1,5-benzothiazepine derivatives
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, (2008/06/13)
Novel 8-chloro-1,5-benzothiazepine derivatives of the formula: STR1 wherein R1 is hydrogen, lower alkyl or a group of the formula: R4 CO--, each of R2 and R3 is lower alkyl and R4 is hydrogen or lower alkyl, and a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and a pharmaceutically acceptable acid addition salt thereof are useful as hypotensive agents and/or coronary or cerebral vasodilators.
