96159-88-5

Basic information

• Product Name: 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole
• Synonyms: 2-{3-nitrophenyl}-4,5-dihydro-1,3-thiazole
• CAS NO: 96159-88-5
• Molecular Formula: C₉H₈N₂O₂S
• Molecular Weight: 208.237
• Mol File: 96159-88-5.mol

Chemical Properties

• Boiling Point: 365°Cat760mmHg
• Flash Point: 174.6°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 3.39E-05mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole(96159-88-5)
• EPA Substance Registry System: 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole(96159-88-5)

Safety Data

• Hazardous Substances Data: 96159-88-5(Hazardous Substances Data)

Usage

Heterocyclic compound

Contains a thiazole ring (five-membered ring with sulfur and nitrogen atoms)

Contains a nitrophenyl group

Benzene ring with a nitro group attached

Used in pharmaceutical industry

As a building block for creating compounds with potential medicinal properties

Potential as an antitumor agent

Has been studied for its ability to inhibit certain enzymes

Potential application in materials science

Investigated for use in the development of fluorescent materials

InChI:InChI=1/C9H8N2O2S/c12-11(13)8-3-1-2-7(6-8)9-10-4-5-14-9/h1-3,6H,4-5H2

Upstream product

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Relevant articles and documents

A single-reagent-driven multistep one-pot preparation of thiazolines and 1,3-thiazines from aldoximes, nitriles, and carboxylic acids

N-(ω-Bromoalkyl)dichlorothiophosphoramidates have been designed as a new class of reagent for the single-reagent-driven multistep preparation of 2-substituted thiazolines and 1,3-thiazines from ald-oximes, nitriles, or carboxylic acids. A wide range of substrates both aromatic as well as aliphatic were investigated and found suitable for the developed protocol.

Trichloroisocyanuric acid as an efficient homogeneous catalyst for the chemoselective synthesis of 2-substituted oxazolines, imidazolines and thiazolines under solvent-free condition

Trichloroisocyanuric acid, as a commercially available and inexpensive catalyst, was used in a new, facile and efficient procedure for the synthesis of 2-oxazolines, 2-imidazolines and 2-thiazolines through the reaction of nitriles with 2-aminoethanol, ethylenediamine or 2-aminoethanethiol under solvent-free conditions.

One-pot synthesis of 2-arylthiazolines with 1-butyl-3-methylimidazolium tribromide as a catalytic reagent

A simple, inexpensive, and efficient one-pot synthesis of 2-arylthiazoline derivatives under solvent-free conditions using a catalytic amount of 1-butyl-3-methylimidazolium tribromide with excellent product yields is reported. This methodology provides ea

Tribromomelamine: A novel and efficient catalyst for the synthesis 2-arylthiazolines under solvent-free conditions

A novel procedure for the synthesis of 2-arylthiazolines through one-pot condensation of of nitriles with 2-aminoethanethiol in the presence of tribromomelamine as catalyst under solvent-free conditions is described.

Easy access to thiazolines and thiazines via tandem S-alkylation- cyclodeamination of thioamides/haloamines

This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.

Research on radioprotective agents: Δ-2 Thiazolines and homologous derivatives

Compounds derived from Δ-2 thiazoline, Δ-2 thiazolinium iodoalkylate and 4,5-dihydro-1,3 thiazine have been prepared and evaluated as potential antiradiation agents in mice. They generally have a low toxicity and significant radioprotective activity.