962-24-3

Basic information

• Product Name: METHYL 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE
• Synonyms: METHYL 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE;2-phenyl-6-imidazo[2,1-f]pyridinecarboxylic acid methyl ester;2-phenylimidazo[2,1-f]pyridine-6-carboxylic acid methyl ester;methyl 2-phenylimidazo[2,1-f]pyridine-6-carboxylate
• CAS NO: 962-24-3
• Molecular Formula: C₁₅H₁₂N₂O₂
• Molecular Weight: 252.27
• Mol File: 962-24-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 181-183°
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.21g/cm³
• Refractive Index: 1.624
• CAS DataBase Reference: METHYL 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE(962-24-3)
• EPA Substance Registry System: METHYL 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE(962-24-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 962-24-3(Hazardous Substances Data)

Usage

General Description

METHYL 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE is a chemical compound with a complex structure. It is a carboxylate ester that contains a phenylimidazo ring and a pyridine ring. METHYL 2-PHENYLIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE has potential applications in pharmaceuticals and organic chemistry as a building block for the synthesis of various compounds. Its specific properties and potential uses would need further examination and research.

InChI:InChI=1/C15H12N2O2/c1-19-15(18)12-7-8-14-16-13(10-17(14)9-12)11-5-3-2-4-6-11/h2-10H,1H3

Upstream product

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Relevant articles and documents

A multi pathway coupled domino strategy: I2/ TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization

I2/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I2/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.

Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents

Free fatty acid receptor 1 (FFA1 or GPR40) has been studied for many years as a target for the treatment of type 2 diabetes mellitus. In order to increase potency and reduce hepatotoxicity, a series of novel compounds containing imidazo[1,2-a]pyridine sca

Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents

The free fatty acid receptor 1 (FFA1) and peroxisome proliferator-activated receptor δ (PPARδ) were considered as potential anti-diabetic targets, and the dual FFA1/PPARδ agonists might provide synergistic effect in insulin secretion and sensibility. Herein, we further develop dual agonists by screening 7 series of heterocycles, resulting in the discovery of compound 19 with considerable oral pharmacokinetic profile. Compound 19 exhibited a balanced potency between FFA1 and PPARδ, and high selectivity over PPARα and PPARγ. Moreover, compound 19 exerted improved glucose-lowering effects and insulin sensitivity in a dose-dependent manner, which might be attributed to its dual effects to simultaneously regulate insulin secretion and resistance. Our results extended the existing chemical space, and provided a potent tool compound 19.