96220-15-4

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Ethylphenyl)-3-oxopropanenitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its chemical structure allows it to be a versatile building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Organic Compounds Synthesis:
3-(4-Ethylphenyl)-3-oxopropanenitrile is utilized as an intermediate in the synthesis of a variety of organic compounds, showcasing its importance in organic chemistry and the creation of new materials with potential applications in different fields.
Used in Agrochemical Production:
3-(4-Ethylphenyl)-3-oxopropanenitrile is employed in the production of agrochemicals, where it plays a crucial role in the development of pesticides, herbicides, and other agricultural chemicals that are essential for crop protection and yield enhancement.
Used in Dyes and Pigments Industry:
3-(4-Ethylphenyl)-3-oxopropanenitrile is also used in the manufacturing of dyes and pigments, where its chemical properties contribute to the creation of vibrant and stable colorants for various applications, including textiles, plastics, and printing inks.
Used in Research and Development:
3-(4-Ethylphenyl)-3-oxopropanenitrile is a valuable compound in research and development within the pharmaceutical and chemical industries. Its unique structure and properties make it an ideal candidate for exploring new chemical reactions and developing innovative products and processes.

InChI:InChI=1/C11H11NO/c1-2-9-3-5-10(6-4-9)11(13)7-8-12/h3-6H,2,7H2,1H3

Upstream product

• 16331-45-6 p-ethylbenzoyl chloride 
• 372-09-8 cyanoacetic acid 
• 25309-64-2 4-ethyl-1-iodobenzene 
• 7364-20-7 4-ethyl-benzoic acid methyl ester 
• 75-05-8 acetonitrile 
• 937-30-4 4-ethylacetophenone 
• 773837-37-9 sodium cyanide 
• 2632-14-6 4-ethylphenacyl bromide 
• 18293-53-3 2-trimethylsilylacetonitrile 
• 13939-06-5 molybdenum hexacarbonyl 
• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

Synthesis of benzoylacetonitriles from Pd-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile

Palladium-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile to produce benzoylacetonitrile derivatives through a one-pot, three-component reaction is described. This preparation method provides good yields of the carbonylated products without any additional ligands. It has a broad substrate scope with a high tolerance for a variety of functional groups.

Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center

A new transformation pattern for enantioselective intramolecular hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals were converted to C3- or C3,C5-chirogenic cyclopentanones with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theoretically calculated and the origin of the stereoselection is rationally explained.

5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS

The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.

Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines

Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines targeting Plasmodium falciparum, the deadliest species of the malaria parasite. Hit compounds in this series display sub-micromolar in vitro activity against the intraerythrocytic stage of the parasite as well as little to no toxicity against the human fibroblast BJ and liver HepG2 cell lines. In addition, our hit compounds show good activity against the liver stage of the parasite but little activity against the gametocyte stage. Parasitological profiles, including rate of killing, docking, and molecular dynamics studies, suggest that our compounds may target the Qo binding site of cytochrome bc1.

Microwave synthesis of 1-aryl-1H-pyrazole-5-amines

A microwave-mediated synthesis of 1H-pyrazole-5-amines utilizing 1 M HCl at 150 °C was developed in order to provide products in a matter of minutes with minimal purification. Most reactions are complete in only 10 min and can be isolated via a simple filtration without the need for further purification by column chromatography or recrystallization. This method tolerates a range of functional groups and can be performed on milligram to gram scales.

One-pot synthesis of benzoylacetonitriles through sequential Pd-catalyzed carbonylation and decarboxylation

Benzoylacetonitrile were prepared through sequential carbonylation and decarboxylation. The palladium-catalyzed carbonylation of aryl iodides and methyl cyanoacetate using Mo(CO)6 as a carbon monoxide source afforded beta-keto cyanoesters, and then the subsequent reaction with Li/H2O produced the desired benzoylacetonitriles.

Palladium-catalyzed carbonylation with Mo(CO)for the synthesis of benzoylacetonitriles

Benzoylacetonitriles were synthesized by the palladium-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile using Mo(CO)as a carbon monoxide source. Pd(PPhCland CuFwere employed as the catalyst and activator, respectively. A variety of aryl iodides bearing alkyl, alkoxy, fluoro, chloro, bromo, nitrile, ester, and ketone groups afforded the corresponding benzoylacetonitriles in moderate to good yields. Georg Thieme Verlag Stuttgart ? New York.

THIOPHENE DERIVATIVES AS PPAR AGONISTS I

The invention discloses compounds of formula (I); wherein: R is a carboxylic acid or a derivative thereof; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkylthio, halo or trihalomethyl; R2 is aryl, heteroaryl, arylalkyl or heteroarylalkyl; R3 is H or F; and L is a linking group comprising a chain of from 2 to 8 atoms linking R and the carbonyl group (A); and pharmaceutically acceptable derivatives thereof, useful for treating disorders mediated by peroxisome-proliferator-activated receptor (PPAR) subtype δ (PPARδ). The compounds of the invention are therefore useful in the treatment of metabolic syndrome, obesity, type-II diabetes, dyslipidemia, wound healing, inflammation, neurodegenerative disorders and multiple sclerosis.

Thienodipyridine derivatives, production and use thereof

A compound of the formula (I): wherein R is hydrogen or C2-6alkanoyl; X is halogen; and ring A is benzene ring which is optionally substituted by 1 to 4 substituents selected from {circle around (1)} halogen, {circle around (2)} hydroxy, {circl