96256-39-2Relevant academic research and scientific papers
Method for preparing fluoroalkane substituted compound by reducing halogenated fluoroalkane and olefin through metal elementary substance
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Paragraph 0061-0069; 0124-0132, (2021/07/17)
The invention discloses a method for preparing a fluoroalkane substituted compound, which comprises the steps of taking a compound containing carbon-carbon double bonds and halogenated fluoroalkane as raw materials, taking a metal elementary substance as a reducing agent, taking a substance containing active protons as a hydrogen source, and carrying out an addition reaction to prepare a compound which is simultaneously substituted by hydrogen and fluoroalkyl, thereby obtaining the fluoroalkane substituted compound. According to the method, the metal elementary substance is used as the reducing agent for the first time, the compound containing active hydrogen is used as the hydrogen source, one hydrogen atom and one fluoroalkyl group are introduced to the two ends of olefin respectively, only one-step reaction is needed, the reaction process conditions are mild, the reaction raw materials are cheap and easy to obtain, the cost is low, and all reaction reagents are green and environmentally friendly; and the reaction substrate has strong applicability, can participate in the reaction as long as carbon-carbon double bonds exist in the structure, and is not influenced by the types of substituent groups on carbon atoms of the double bonds, and the yield of the product is good.
Practical Photocatalytic Trifluoromethylation and Hydrotrifluoromethylation of Styrenes in Batch and Flow
Straathof, Natan J. W.,Cramer, Sten E.,Hessel, Volker,No?l, Timothy
supporting information, p. 15549 - 15553 (2016/12/09)
Styrenes represent a challenging class of substrates for current radical trifluoromethylation and hydrotrifluoromethylation methods due to a myriad of potential side reactions. Herein, we describe the development of mild, selective and broadly applicable photocatalytic trifluoromethylation and hydrotrifluoromethylation protocols for these challenging substrates. The methods use fac-Ir(ppy)3, visible light and inexpensive CF3I and can be applied to a diverse set of vinylarene substrates. The use of continuous-flow photochemical reaction conditions allowed to reduce the reaction time and increase the reaction selectivity.
Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
Kobayashi, Yoshiro,Nagai, Takabumi,Kumadaki, Itsumaro,Takahashi, Masaaki,Yamauchi, Takashi
, p. 4382 - 4387 (2007/10/02)
The Friedel-Crafts reaction of 1,1,1-trifluoropropene with benzene and its derivatives was accomplished in the presence of fluorine-containing acid catalysts.The reaction proceeded at the terminal carbon atom of the olefin to give 3,3,3-trifluoropropylated aromatic compounds.The scope and limitations of this reaction were examined.This substituent was found to be ortho- and para-directing.Keywords - Friedel-Crafts reaction; trifluoropropene; trifluoropropyl; Nafion-H; hydrogen fluoride; boron trifluoride; tetrafluoroboric acid; benzene; trifluoropropylation
