58337-16-9

Basic information

• Product Name: ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE
• Synonyms: BUTTPARK 83\07-49;ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE;ETHYL 5-OXO-2-(PHENYLAMINO)-3-OXOLENECARBOXYLATE
• CAS NO: 58337-16-9
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.25
• Mol File: 58337-16-9.mol

Chemical Properties

• Melting Point: 118-120°C
• Boiling Point: 377.2°Cat760mmHg
• Flash Point: 182°C
• Appearance: /
• Density: 1.339g/cm³
• Vapor Pressure: 6.84E-06mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE(58337-16-9)
• EPA Substance Registry System: ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE(58337-16-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 58337-16-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, particularly in the context of medicinal chemistry.
Used in Chemical Research:
In the field of chemical research, ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE serves as a subject of study for understanding the properties and reactions of complex organic molecules. It can be used to explore new reaction pathways and mechanisms, contributing to the advancement of organic chemistry.
Used in Industrial Applications:
ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-FURANCARBOXYLATE may also find use in industrial applications where its specific chemical properties are required for the production of certain materials or products. Its role in these applications would be determined by its reactivity, stability, and compatibility with other substances in the manufacturing process.

InChI:InChI=1/C13H13NO4/c1-2-17-13(16)11-10(15)8-18-12(11)14-9-6-4-3-5-7-9/h3-7,14H,2,8H2,1H3

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 103-71-9 phenyl isocyanate 
• 105-53-3 diethyl malonate 
• 79-04-9 chloroacetyl chloride 
• 62-53-3 aniline 
• 36717-48-3 Ethyl 2-ethoxy-4-oxo-4,5-dihydrofuran-3-carboxylate 

Downstream Products

• 484-29-7 dictamnine 
• 1314653-81-0 ethyl 4-chloro-5-[4-ethoxycarbonyl-3-oxo-5-(phenylamino)furan-2(3H)-ylidene]methyl-2-(phenylamino)furan-3-carboxylate 
• 1314653-80-9 ethyl 4-chloro-5-(2,2-dicyanovinyl)-2-(phenylamino)furan-3-carboxylate 
• 1314653-74-1 ethyl 5-amino-2-{[hydroxy(phenyl)methyl](phenyl)amino}-7-phenyl-4,6-dicyano-1-benzofuran-3-carboxylate 
• 96286-63-4 N-(4-methylphenyl)-4,5-dihydro-4-oxo-2-(phenylamino)-3-furancarboxamide 
• 1314653-77-4 ethyl 4-chloro-5-formyl-2-(phenylamino)furan-3-carboxylate 
• 1402057-46-8 2-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-5-(phenylamino)furan-3(2H)-one 
• 1402055-32-6 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid 
• 484-74-2 iso-dictamnine 
• 58337-20-5 ethyl-4,5-dihydro-4-oxo-2<(N-methyl)phenylamino>-3-furancarboxylate 
• 115321-04-5 4,5-dihydro-4-oxo-2-(phenylamino)-3-furancarboxylic acid sodium salt 
• 115716-73-9 potassium 2,5-dihydro-3-ethoxycarbonyl-2-phenylimino-4-furanyloxide 
• 129206-04-8 2-anilino-4-oxo-4,5-dihydrofuran 
• 58337-23-8 2-(N-phenylamino)-4,5-dihydro-4-oxo-3-furancarboxylic acid 

Relevant articles and documents

Synthesis, design, and structure–activity relationship of the pyrimidone derivatives as novel selective inhibitors of plasmodium falciparum dihydroorotate dehydrogenase

The inhibition of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) potentially represents a new treatment option for malaria, as P. falciparum relies entirely on a de novo pyrimidine biosynthetic pathway for survival. Herein, we report a series of pyrimidone derivatives as novel inhibitors of PfDHODH. The most potent compound, 26, showed high inhibition activity against PfDHODH (IC50 = 23 nM), with >400-fold species selectivity over human dihydroorotate dehydrogenase (hDHODH). The brand-new inhibitor scaffold targeting PfDHODH reported in this work may lead to the discovery of new antimalarial agents.

METHOD FOR TREATING VIRUS INFECTION USING DERIVATIVE OF ANILINE

A method for treating a virus infection in a subject is provided. The method comprising administering to the subject in need an effective amount of a derivative of aniline selected from the group consisting of a compound of formula (I), a pharmaceutically

Drug-induced modifications of the immune response. 12. 4,5-Dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids and derivatives as novel antiallergic agents

The synthesis of a series of novel 4,5-dihydro-4-oxo-2-(substituted amino)-3-furancarboxylic acids, salts, esters, and amides is described. The title compounds when tested in the mediator-induced dermal vascular permeability and active anaphylaxis assays in rats demonstrated moderate to potent antiallergic activity. The [2-trans-(4-methyl-phenyl)cyclopropyl]amino analogue 53 emerged as the most active derivative. Thus, when administered intraperitoneally to rate at a dose of 100 mg/kg, it inhibited the action of the mediators serotonin, histamine, and bradykinin by 100%. In the active anaphylaxis assay in rats, compound 30 suppressed the edema by 81% at a dose of 100 mg/kg, following intraperitoneal administration.